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Titolo:
Synthesis and in vitro evaluation of I-123-labelled human recombinant annexin V
Autore:
Lahorte, C; Slegers, G; Philippe, J; Van de Wiele, C; Dierckx, RA;
Indirizzi:
Fac Pharmaceut Sci, Dept Radiopharm, B-9000 Ghent, Belgium Fac Pharmaceut Sci Ghent Belgium B-9000 adiopharm, B-9000 Ghent, Belgium State Univ Ghent Hosp, Dept Biol Clin, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 l Clin, B-9000 Ghent, Belgium State Univ Ghent Hosp, Dept Nucl Med, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 cl Med, B-9000 Ghent, Belgium
Titolo Testata:
BIOMOLECULAR ENGINEERING
fascicolo: 2, volume: 17, anno: 2001,
pagine: 51 - 53
SICI:
1389-0344(200101)17:2<51:SAIVEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; PHOSPHATIDYLSERINE; APOPTOSIS;
Keywords:
annexin V; apoptosis; I-123-labelling; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Lahorte, C Fac Pharmaceut Sci, Dept Radiopharm, Harelbekestr 72, B-9000 Ghent, Belgium Fac Pharmaceut Sci Harelbekestr 72 Ghent Belgium B-9000 elgium
Citazione:
C. Lahorte et al., "Synthesis and in vitro evaluation of I-123-labelled human recombinant annexin V", BIOMOL ENG, 17(2), 2001, pp. 51-53

Abstract

Annexin V was radiolabelled with iodine-123 in order to develop a SPECT-ligand for imaging atherosclerosis and apoptosis. Iodination by means of electrophylic substitution resulted in radiochemical yields up to 70% and specific activities of 7.4-92.5 MBq/mug protein. Binding experiments with blood platelets indicated that I-123-labelled annexin V remained its biological activity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:07:28