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Titolo:
Hippocampal rhythm generation: Gamma-related theta-frequency resonance in CA3 interneurons
Autore:
Orban, G; Kiss, T; Lengyel, M; Erdi, P;
Indirizzi:
Hungarian Acad Sci, KFKI Res Inst Particle & Nucl Phys, Dept Biophys, H-1525 Budapest, Hungary Hungarian Acad Sci Budapest Hungary H-1525 hys, H-1525 Budapest, Hungary
Titolo Testata:
BIOLOGICAL CYBERNETICS
fascicolo: 2, volume: 84, anno: 2001,
pagine: 123 - 132
SICI:
0340-1200(200102)84:2<123:HRGGTR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-POTENTIAL OSCILLATIONS; URETHANE ANESTHETIZED RATS; ENTORHINAL CORTEX; BEHAVING RAT; NEURONAL OSCILLATIONS; PYRAMIDAL CELLS; SEPTAL NEURONS; SEQUENCES; NETWORKS; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Erdi, P Hungarian Acad Sci, KFKI Res Inst Particle & Nucl Phys, Dept Biophys, POB 49, H-1525 Budapest, Hungary Hungarian Acad Sci POB 49 Budapest Hungary H-1525 dapest, Hungary
Citazione:
G. Orban et al., "Hippocampal rhythm generation: Gamma-related theta-frequency resonance in CA3 interneurons", BIOL CYBERN, 84(2), 2001, pp. 123-132

Abstract

During different behavioral states different population activities are present in the hippocampal formation. These activities are not independent: sharp waves often occur together with high-frequency ripples, and gamma-frequency activity is usually superimposed on theta oscillations. There is both experimental and theoretical evidence supporting the notion that gamma oscillation is generated intrahippocampally, but there is no generally acceptedview about the origin of theta waves. Precise timing of population bursts of pyramidal cells may be due to a synchronized external drive. Membrane potential oscillations recorded in the septum are unlikely to fulfill this purpose because they are not coherent enough. We investigated the prospects of an intrahippocampal mechanism supplying pyramidal cells with theta frequency periodic inhibition, by studying a model of a network of hippocampal inhibitory interneurons. As shown previously, interneurons are capable of generating synchronized gamma-frequency action potential oscillations. Exciting the neurons by periodic current injection, the system could either be entrained in an oscillation with the frequency of the inducing current or exhibit in-phase periodic changes at the frequency of single cell (and network)activity. Simulations that used spatially inhomogeneous stimulus currents showed antiphase frequency changes across cells, which resulted in a periodic decrease in the synchrony of the network. As this periodic change in synchrony occurred in the theta frequency range, our network should be able toexhibit the theta-frequency weakening of inhibition of pyramidal cells, thus offering a possible mechanism for intrahippocampal theta generation.

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Documento generato il 06/04/20 alle ore 07:33:59