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Titolo:
Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer
Autore:
Kobayashi, H; Sato, N; Kawamoto, S; Saga, T; Hiraga, A; Haque, TL; Ishimori, T; Konishi, J; Togashi, K; Brechbiel, MW;
Indirizzi:
Hitachi Med Co, Dept Diagnost & Intervent Imagiol, Kyoto 6068507, Japan Hitachi Med Co Kyoto Japan 6068507 tervent Imagiol, Kyoto 6068507, Japan Hitachi Med Co, Dept Nucl Med & Diagnost Imaging, Kyoto 6068507, Japan Hitachi Med Co Kyoto Japan 6068507 iagnost Imaging, Kyoto 6068507, Japan Kyoto Univ, Dept Radiol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 o Univ, Dept Radiol, Kyoto 6068507, Japan Otsu Municipal Hosp, Dept Radiol, Otsu, Shiga 5200804, Japan Otsu Municipal Hosp Otsu Shiga Japan 5200804 , Otsu, Shiga 5200804, Japan NCI, Chem Sect, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 adiat Oncol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
BIOCONJUGATE CHEMISTRY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 100 - 107
SICI:
1043-1802(200101/02)12:1<100:COTMMC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY; GD-DTPA; ANGIOGRAPHY; FLEXIBILITY; MEDIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, H Hitachi Med Co, Dept Diagnost & Intervent Imagiol, Kyoto 6068507, Japan Hitachi Med Co Kyoto Japan 6068507 ol, Kyoto 6068507, Japan
Citazione:
H. Kobayashi et al., "Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer", BIOCONJ CHE, 12(1), 2001, pp. 100-107

Abstract

Two novel macromolecular MRI contrast agents based upon generation-6 polyamidoamine dendrimers (G6) of presumed similar molecular size, but of different molecular weight, were compared in terms of their blood retention, tissue distribution, and renal excretion. Two G6s with either ammonia core (G6A) or with ethylenediamine core (G6E), which possessed 192 and 256 exterior primary amino groups, respectively, were used. These dendrimers were reacted with 2-(p-isothiocyanatobenzyl)-6-methyldiethylenetriaminepentaacetic acid (1B4M). The G6-IB4M conjugates were reacted with Gd-153 for studying biodistribution and blood clearance or Gd(III) for the MRI study. 3D-micro-MR angiography of the mice were taken with injection of 0.033 mmol of Gd/kg of G6A-(1B4M-Gd)(192) or G6E-(1B4M-Gd)(256) using a 1.5-T superconductive MRI unit. Although numerous fine vessels of similar to 100 mum diameter were visualized on subtracted 3D-MR-angiography with both G6A-(1B4M-Gd)(192) and G6E-(1B4M-Gd)(256), Gd-153-labeled saturated G6E-(1B4M)(256) remained in theblood significantly more than Gd-153-labeled saturated G6A-(1B4M)(192) at later than 15 min postinjection (p < 0.01). In addition, G6E-(IB4M-Gd)(256)visualized these finer vessels longer than G6A-(1B4M-Gd)(192). The G6A-(1B4M-Gd)(192) showed higher signal intensity in the kidney on the dynamic MR images and brighter kidney images than G6E-(1B4M-Gd)(256). In conclusion, the G6A-(1B4M-Gd)(192) was observed to go through glomerular filtration moreefficiently than G6E-(1B4M-Gd)(256) resulting faster clearance from the blood and higher renal accumulation, even though both of G6-1B4M conjugates have almost similar molecular size and same chemical structure. In terms of the ability of intravascular contrast agents, G6E-(1B4M-Gd)(256) was betterdue to more Gd(III) atoms per molecule and longer retention in the circulation than G6A-(1B4M-Gd)(192).

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Documento generato il 05/04/20 alle ore 19:43:07