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Titolo:
The polyamine stress response: tissue-, endocrine-, and developmental-dependent regulation
Autore:
Gilad, VH; Rabey, JM; Kimiagar, Y; Gilad, GM;
Indirizzi:
Assaf Harofeh Med Ctr, Lab Neurosci Res & Dev, IL-70300 Zerifin, Israel Assaf Harofeh Med Ctr Zerifin Israel IL-70300 , IL-70300 Zerifin, Israel Assaf Harofeh Med Ctr, Dept Neurol, IL-70300 Zerifin, Israel Assaf HarofehMed Ctr Zerifin Israel IL-70300 , IL-70300 Zerifin, Israel
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 2, volume: 61, anno: 2001,
pagine: 207 - 213
SICI:
0006-2952(20010115)61:2<207:TPSRTE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORNITHINE DECARBOXYLASE ACTIVITY; BIOCHEMICAL MANIFESTATIONS; INDUCED INCREASE; CELL-DEATH; HEAT-SHOCK; RAT-BRAIN; DEXAMETHASONE; GLUCOCORTICOIDS; DEPRESSION; CORTICOSTERONE;
Keywords:
adrenalectomy; brain; developmental regulation; dexamethasone treatment; liver; ornithine decarboxylase activity; putrescine; restraint stress; spermidine; spermine; thymus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gilad, GM Assaf Harofeh Med Ctr, Lab Neurosci Res & Dev, IL-70300 Zerifin,Israel Assaf Harofeh Med Ctr Zerifin Israel IL-70300 Zerifin, Israel
Citazione:
V.H. Gilad et al., "The polyamine stress response: tissue-, endocrine-, and developmental-dependent regulation", BIOCH PHARM, 61(2), 2001, pp. 207-213

Abstract

Transient alterations in polyamine (PA) metabolism, termed the polyamine stress response (PSR), constitute a common cellular response to stressful stimuli. In contrast to the adult brain and liver, the PSR in the adrenal gland and thymus is characterized by a reduction in PA metabolism. The brain PSR undergoes an early postnatal period of non-responsiveness. The aim of the present study was twofold: i) to determine whether the PSR in the liver, thymus, and adrenal gland is developmentally regulated as that in the brainand ii) to establish whether neuronal and hormonal signals can activate the PSR independently. Ornithine decarboxylase (ODC) activity and tissue PA concentrations served as markers of the PSR. Changes were measured in male Wistar rats during postnatal development and at 2 weeks after adrenalectomy in adults. Unlike the brain, the direction of the PSR in peripheral organs did not undergo developmental changes. After adrenalectomy, the PSR was notactivated in the thymus and liver by acute (2-hr) restraint stress, but a characteristic PSR was induced in the hippocampus. However, dexamethasone injection (3 mg/kg) did induce a characteristic PSR in all organs of adrenalectomized rats. The results justify the following conclusions: i) Unlike peripheral organs, the PSR in the brain is developmentally regulated; ii) Thedevelopmental switch to a mature PSR in the brain corresponds in time to the cessation of the "stress hypo-responsive period" in the hypothalamic-pituitary-adrenocortical (HPA) axis; iii) In the periphery, the PSR appears tobe dependent principally on stress-induced activation of the HPA axis and on increased circulating glucocorticoid concentrations rather than on neuronal activation; iv) In the brain, however, the PSR can be induced independently by glucocorticoids or by direct activation of the neuronal circuitry; and v) up-regulation of the PSR, as in the brain and liver, is constructiveand may be implicated in cell survival, while its down-regulation, as in the adrenal and thymus, may be implicated in cell death. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:56:52