Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interaction of calcitonin gene-related peptide (CGRP), substance P (SP) and conventional autonomic agonists in rat submandibular salivary peroxidase release in vitro
Autore:
Soinila, J; Soinila, S;
Indirizzi:
Univ Turku, Inst Dent, Dept Oral & Maxillofacial Surg, Turku, Finland UnivTurku Turku Finland Dept Oral & Maxillofacial Surg, Turku, Finland Cent Hosp Cent Finland, Dept Oral & Maxillofacial Surg, FIN-40620 Jyvaskyla, Finland Cent Hosp Cent Finland Jyvaskyla Finland FIN-40620 20 Jyvaskyla, Finland Univ Helsinki, Inst Biomed, Helsinki, Finland Univ Helsinki Helsinki Finland Helsinki, Inst Biomed, Helsinki, Finland Univ Helsinki, Dept Neurol, FIN-00290 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00290 ol, FIN-00290 Helsinki, Finland
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 3, volume: 86, anno: 2001,
pagine: 163 - 169
SICI:
1566-0702(20010114)86:3<163:IOCGP(>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOHISTOCHEMICAL LOCALIZATION; PARASYMPATHETIC NEURONS; BINDING-SITES; PAROTID-GLAND; NERVE-FIBERS; SECRETION; GANGLIA; PROTEIN; SLICES; ORIGIN;
Keywords:
calcitonin gene-related peptide; substance P; autonomic agonists; submandibular; salivary glands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Soinila, J Univ Turku, Inst Dent, Dept Oral & Maxillofacial Surg, Turku, Finland Univ Turku Turku Finland Maxillofacial Surg, Turku, Finland
Citazione:
J. Soinila e S. Soinila, "Interaction of calcitonin gene-related peptide (CGRP), substance P (SP) and conventional autonomic agonists in rat submandibular salivary peroxidase release in vitro", AUTON NEURO, 86(3), 2001, pp. 163-169

Abstract

Our previous immunohistochemical studies reveal that several neuropeptides, such as substance P and calcitonin gene-related peptide, innervate the major salivary glands of the mouse, rat and human. The aim of the study was to clarify their interactions by measuring their effects alone or with conventional autonomic agonists (carbachol, phenylephrine and isoproterenol) on peroxidase secretion of incubated submandibular gland slices. Calcitonin gene-related peptide evoked significant increase in peroxidase activity of the secretion only when used at 10(-5) M concentration, while substance P evoked significant, dose-dependent increase at much lower concentrations (10(-10) M). Adrenergic and cholinergic agonists enhanced peroxidase activity. Interestingly, substance P inhibited both phenylephrine and isoproterenol induced increase in peroxidase activity. Calcitonin gene-related peptide did not affect the inhibition caused by substance P. Our results demonstrate that in the salivary gland tissue substance P alone or in conjunction with adrenergic agonists result in opposing secretory responses with the doses used in vitro. Conversely, the response mediated by adrenergic receptors may be critically affected by simultaneous occupation of substance P receptors. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:42:43