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Titolo:
High density lipoproteins and arteriosclerosis - Role of cholesterol efflux and reverse cholesterol transport
Autore:
von Eckardstein, A; Nofer, JR; Assmann, G;
Indirizzi:
Univ Munster, Zent Lab, Inst Klin Chem & Lab Med, D-48129 Munster, GermanyUniv Munster Munster Germany D-48129 & Lab Med, D-48129 Munster, Germany Univ Munster, Inst Arterioskleroseforsch, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 eroseforsch, D-4400 Munster, Germany
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 13 - 27
SICI:
1079-5642(200101)21:1<13:HDLAA->2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; ESTER TRANSFER PROTEIN; CORONARY HEART-DISEASE; SCAVENGER RECEPTOR BI; E-DEFICIENT MICE; BINDING CASSETTE TRANSPORTER-1; PHOSPHOLIPID TRANSFER PROTEIN; HUMAN SKIN FIBROBLASTS; TRIGLYCERIDE-RICH LIPOPROTEINS; MONOCYTE-DERIVED MACROPHAGES;
Keywords:
apolipoproteins; lipid transfer proteins; lipases; ABC transporter; Tangier disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
216
Recensione:
Indirizzi per estratti:
Indirizzo: von Eckardstein, A Univ Munster, Zent Lab, Inst Klin Chem & Lab Med, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
A. von Eckardstein et al., "High density lipoproteins and arteriosclerosis - Role of cholesterol efflux and reverse cholesterol transport", ART THROM V, 21(1), 2001, pp. 13-27

Abstract

High density lipoprotein (HDL) cholesterol is an important risk factor forcoronary heart disease, and HDL exerts various potentially antiatherogenicproperties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs. Enhancement of cholesterol efflux and of reverse cholesterol transport (RCT) is considered an important target for antiatherosclerotic drug therapy. Levels and composition of HDL subclasses in plasma are regulated by many factors, including apolipoproteins, lipolytic enzymes, lipid transfer proteins, receptors, and cellular transporters. In vitro experiments as well as genetic family and population studies and investigation of transgenic animal models have revealed that HDL cholesterol plasma levels do not necessarily reflectthe efficacy and antiatherogenicity of RCT. Instead, the concentration of HDL subclasses, the mobilization of cellular lipids for afflux, and the kinetics of HDL metabolism are important determinants of RCT and the risk of atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:25:36