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Titolo:
Estrogen and angiogenesis - A review
Autore:
Losordo, DW; Isner, JM;
Indirizzi:
St Elizabeths Med Ctr, Div Cardiovasc Med, Boston, MA 02135 USA St Elizabeths Med Ctr Boston MA USA 02135 ovasc Med, Boston, MA 02135 USA St Elizabeths Med Ctr, Div Res, Boston, MA 02135 USA St Elizabeths Med Ctr Boston MA USA 02135 , Div Res, Boston, MA 02135 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 6 - 12
SICI:
1079-5642(200101)21:1<6:EAA-AR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE SYNTHASE; NATURAL-KILLER-CELLS; CORONARY-ARTERY OCCLUSION; MESSENGER-RNA EXPRESSION; TUMOR ANGIOGENESIS; BREAST-CANCER; BONE-MARROW; INHIBITS ANGIOGENESIS; BLOOD-VESSELS;
Keywords:
estrogen; angiogenesis; vasculogenesis; endothelium; endothelial progenitor cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Losordo, DW St Elizabeths Med Ctr, Div Cardiovasc Med, 736 Cambridge St, Boston, MA 02135 USA St Elizabeths Med Ctr 736 Cambridge St Boston MA USA 02135 USA
Citazione:
D.W. Losordo e J.M. Isner, "Estrogen and angiogenesis - A review", ART THROM V, 21(1), 2001, pp. 6-12

Abstract

Multiple lines of evidence suggest that estrogen directly modulates angiogenesis via effects on endothelial cells. Under physiological conditions, angiogenesis is routinely observed in the uterus in association with fluctuations in the levels of circulating estradiol and other sex steroids. In pathological circumstances, such as breast cancer, a clear association between estrogen, estrogen receptor expression by endothelial cells, angiogenic activity, and/or tumor invasiveness has been made. Studies performed in our laboratory have revealed that estradiol accelerates functional endothelial recovery after arterial injury. Despite these consistent observations, the mechanisms by which estrogen regulates angiogenesis under physiological and pathological circumstances have not been defined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:06:18