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Titolo:
Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats
Autore:
Miliar, A; Serra, D; Casaroli, R; Vilaro, S; Asins, G; Hegardt, FG;
Indirizzi:
Univ Barcelona, Fac Farm, Dept Biochem & Mol Biol, Sch Pharm, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 h Pharm, E-08028 Barcelona, Spain Univ Barcelona, Sch Biol, Cell Biol Unit, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 ol Unit, E-08028 Barcelona, Spain
Titolo Testata:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
fascicolo: 2, volume: 385, anno: 2001,
pagine: 283 - 289
SICI:
0003-9861(20010115)385:2<283:DCICOG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID OXIDATION; PALMITOYLTRANSFERASE-I; MOLECULAR-CLONING; PERINATAL-PERIOD; MALONYL-COA; KETOGENESIS; CDNA; ADAPTATIONS; METABOLISM; ENZYMES;
Keywords:
suckling rats; carnitine octanoyltransferase; peroxisomes; ketogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hegardt, FG Univ Barcelona, Fac Farm, Dept Biochem & Mol Biol, Sch Pharm, Diagonal 643, E-08028 Barcelona, Spain Univ Barcelona Diagonal 643 Barcelona Spain E-08028 na, Spain
Citazione:
A. Miliar et al., "Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats", ARCH BIOCH, 385(2), 2001, pp. 283-289

Abstract

Carnitine octanoyltransferase (COT), which facilitates the transport of shortened fatty acyl-CoAs from peroxisomes to mitochondria, is expressed in the intestinal mucosa of suckling rats; its mRNA levels increase rapidly after birth, remain steady until day 15, and decrease until weaning, when basal, adult values are established, which remain unchanged thereafter. The process seems to be controlled at the transcriptional level since the developmental pattern of mRNA coincides with that of pre-mRNA values. Dam's milk may influence the intestinal expression of GOT, since mRNA levels at birth are low and increase after the first lactation. Moreover, mRNA levels decrease in rats weaned on day 18 or 21, COT is also expressed in the liver of suckling rats. Hepatic COT mRNA is maximal at day 3, remains constant until day 9, and decreases thereafter; this pattern is also similar to that of pre-mRNA values. The profile of expression of COT in intestine and liver strongly resembles that of mitochondrial 3-hydroxy 3-methylglutaryl-coenzyme A synthase and carnitine palmitoyltransferase I, suggesting that analogous transcription factors modulate ketogenesis and mitochondrial and peroxisomal fatty acid oxidation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:30:56