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Titolo:
Review: Nasal toxicity, carcinogenicity, and olfactory uptake of metals
Autore:
Sunderman, FW;
Indirizzi:
Middlebury Coll, Dept Chem & Biochem, Middlebury, VT 05753 USA Middlebury Coll Middlebury VT USA 05753 Biochem, Middlebury, VT 05753 USA Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA
Titolo Testata:
ANNALS OF CLINICAL AND LABORATORY SCIENCE
fascicolo: 1, volume: 31, anno: 2001,
pagine: 3 - 24
SICI:
0091-7370(200101)31:1<3:RNTCAO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RETIRED NICKEL WORKERS; CARNOSINE-LIKE IMMUNOREACTIVITY; ZINC-SULFATE TREATMENT; TROUT SALMO-TRUTTA; ALZHEIMERS-DISEASE; SUBCELLULAR-DISTRIBUTION; REGIONAL DISTRIBUTION; PARKINSONS-DISEASE; HOMING BEHAVIOR;
Keywords:
rhinotoxicity; anosmia; nasal perforation; sinonasal cancer; olfactory nerve; olfactory bulb; aluminum; arsenic; bismuth; cadmium; chromium; cobalt; copper; mercury; manganese; nickel; zinc;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
166
Recensione:
Indirizzi per estratti:
Indirizzo: Sunderman, FW 27D Barnes Rd, Whiting, VT 05778 USA 27D Barnes Rd Whiting VT USA 05778 d, Whiting, VT 05778 USA
Citazione:
F.W. Sunderman, "Review: Nasal toxicity, carcinogenicity, and olfactory uptake of metals", ANN CLIN L, 31(1), 2001, pp. 3-24

Abstract

Occupational exposures to inhalation of certain metal dusts or aerosols can cause loss of olfactory acuity, atrophy of the nasal mucosa, mucosal ulcers, perforated nasal septum, or sinonasal cancer. Anosmia and hyposmia havebeen observed in workers exposed to Ni- or Cd-containing dusts in alkalinebattery factories, nickel refineries, and cadmium industries. Ulcers of the nasal mucosa and perforated nasal septum have been reported in workers exposed to Cr(VI) in chromate production and chrome plating, or to As(III) inarsenic smelters. Atrophy of the olfactory epithelium has been observed inrodents following inhalation of NiSO4 or alpha Ni3S2. Cancers of the nose and nasal sinuses have been reported in workers exposed to Ni compounds in nickel refining, cutlery factories, and alkaline battery manufacture, or toCr(VI) in chromate production and chrome plating. III animals, several metals (eg, Al, Cd, Co, Hg, Mn, Ni, Zn) have been shown to pass via olfactory receptor neurons from the nasal lumen through the cribriform plate to the olfactory bulb. Some metals (eg. Mn, Ni, Zn) can cross synapses in the olfactory bulb and migrate via secondary olfactory neurons to distant nuclei of the brain. After nasal instillation of a metal-containing solution, transport of the metal via olfactory axons can occur rapidly within hours or a fewdays (eg, Mn), or slowly other days or weeks (eg, Ni). The olfactory bulb tends to accumulate certain metals (eg, Al, Bi, Cu, Mn, Zn) with greater avidity than other regions of the brain. The molecular mechanisms responsiblefor metal translocation in olfactory neurons and deposition in the olfactory bulb are unclear, but complexation by metal-binding molecules such as carnosine (beta -alanyl-L-histidine) may be involved.

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Documento generato il 27/09/20 alle ore 06:56:58