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Titolo:
Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast
Autore:
Simons, FER; Johnston, L; Gu, XC; Simons, KJ;
Indirizzi:
Univ Manitoba, Hlth Sci Clin Res Ctr, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB Canada Sci Clin Res Ctr, Winnipeg, MB, Canada Univ Manitoba, Fac Pharm, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 rm, Winnipeg, MB R3T 2N2, Canada Univ Manitoba, Fac Med, Winnipeg, MB R3T 2N2, Canada Univ Manitoba Winnipeg MB Canada R3T 2N2 ed, Winnipeg, MB R3T 2N2, Canada
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 1, volume: 86, anno: 2001,
pagine: 44 - 50
SICI:
1081-1206(200101)86:1<44:SOTEAL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOTRIENE RECEPTOR ANTAGONIST; HUMAN-SKIN; INFLAMMATORY RESPONSES; MEDIATOR RELEASE; HISTAMINE; CETIRIZINE; ASTHMA; PERMEABILITY; PREDNISOLONE; TERFENADINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Simons, FER Childrens Hosp Winnipeg, 820 Sherbrook St, Winnipeg, MB R3A 1R9, Canada Childrens Hosp Winnipeg 820 Sherbrook St Winnipeg MB Canada R3A 1R9
Citazione:
F.E.R. Simons et al., "Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast", ANN ALLER A, 86(1), 2001, pp. 44-50

Abstract

Background: The relative contribution of histamine and the cysteinyl leukotrienes to the early and late cutaneous allergic responses (ECAR and LCAR) can be studied using antagonists of these mediators. Objective: To determine the relative suppression of the ECARs and LCARs using standard doses of an H-1-receptor antagonist, a cysteinyl leukotriene(1)-receptor antagonist, and the two antagonists administered concurrently. Methods: We carried out a prospective, randomized, double-blind, placebo-controlled, four-way crossover study in 12 highly allergic participants. Intradermal tests with standardized allergen, and with histamine phosphate, LTD4, and saline controls were performed on 5 different test days as follows:pretreatment baseline and at steady state immediately after the seventh and last dose of a 1-week course of treatment with once-daily fexofenadine, 120 mg; montelukast, 10 mg; fexofenadine and montelukast administered concurrently; or placebo. On each test day, the skin test results were read at intervals from 0.25 to 24 hours after the intradermal injections were performed. Results: After allergen injection, compared with baseline, all treatment regimens significantly decreased the ECAR and LCAR. After allergen injection, compared with placebo, fexofenadine significantly decreased the ECAR and the LCAR from 0.25 to 2 hours and at 8 hours. Montelukast did not significantly decrease the ECAR or LCAR. Fexofenadine and montelukast administered concurrently were not more effective than fexofenadine alone at any time. Inthe control skin tests, compared with placebo, fexofenadine, but not montelukast, significantly decreased the histamine-induced response, and montelukast, but not fexofenadine, significantly decreased the LTD4-induced response. Conclusions: Fexofenadine and montelukast administered concurrently were not significantly more effective than fexofenadine alone in decreasing the ECAR and LCAR. Montelukast does not need to be discontinued before allergen skin testing. Further studies of the effect of concurrent treatment with higher doses of a histamine antagonist and a leukotriene modifier on the allergic response in the skin are needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 07:50:28