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Titolo:
Reproducibility of hippocampal single-voxel proton MR spectroscopy and chemical shift imaging
Autore:
Hsu, YY; Chen, MC; Lim, KE; Chang, C;
Indirizzi:
Chang Gung Mem Hosp, Dept Radiol, Taipei 105, Taiwan Chang Gung Mem Hosp Taipei Taiwan 105 p, Dept Radiol, Taipei 105, Taiwan Chang Gung Univ, Dept Publ Hlth, Taoyuan 333, Taiwan Chang Gung Univ Taoyuan Taiwan 333 , Dept Publ Hlth, Taoyuan 333, Taiwan Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 inica, Inst Biomed Sci, Taipei 115, Taiwan
Titolo Testata:
AMERICAN JOURNAL OF ROENTGENOLOGY
fascicolo: 2, volume: 176, anno: 2001,
pagine: 529 - 536
SICI:
0361-803X(200102)176:2<529:ROHSPM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; MAGNETIC-RESONANCE SPECTROSCOPY; HUMAN-BRAIN INVIVO; LATERALIZATION; NMR; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hsu, YY Chang Gung Mem Hosp, Dept Radiol, 199 Tung Hwa N Rd, Taipei 105, Taiwan Chang Gung Mem Hosp 199 Tung Hwa N Rd Taipei Taiwan 105 5, Taiwan
Citazione:
Y.Y. Hsu et al., "Reproducibility of hippocampal single-voxel proton MR spectroscopy and chemical shift imaging", AM J ROENTG, 176(2), 2001, pp. 529-536

Abstract

OBJECTIVE. We investigated between- and within-acquisition reproducibilityof hippocampal metabolite ratios obtained using automated proton MR spectroscopy,SUBJECTS AND METHODS, We examined 30 healthy adults with a 1.5-T scanner four times on 3 days using single-voxel spectroscopy over the left hippocampus, chemical shift imaging over the left hippocampus. and chemical shift imaging over the bilateral hippocampi, Metabolite ratios were derived from the integral values of three major peaks: N-acetyl-aspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr). The random-effects model of one-way analysis of variance was used to evaluate the reproducibility in terms of coefficient of variation; the mixed-effects model was used to compare the results of different hippocampal regions and spectroscopic techniques. RESULTS. Most coefficients of variation fur the NAA/(Cho+Cr) ratio were less than 20%, All the coefficients of variation for the posterior hippocampus (15-25%) were less than those for the anterior hippocampus (20-44%), The posterior hippocampal NAA/(Cho+Cr) ratio of unilateral chemical shift imaging had the lowest coefficient of variation (<16%). Single voxel spectroscopy and unilateral chemical shift imaging had similar coefficients of variation for the anterior hippocampal NAA/(Cho+Cr) ratios (17-20%). There was a significant difference in metabolite ratios measured in different hippocampal regions (p < 0.01) and in those acquired with different spectroscopic techniques (p < 0.001),CONCLUSION. The NAA/(Cho+Cr) ratio is the most reproducible parameter for hippocampal MR spectroscopy on a 1.5-T scanner. Regional variation and technical differences in metabolite ratios must be considered when interpretingproton spectra of the hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:05:40