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Titolo:
Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study
Autore:
Shahar, E; Whitney, CW; Redline, S; Lee, ET; Newman, AB; Nieto, FJ; OConnor, GT; Boland, LL; Schwartz, JE; Samet, JM;
Indirizzi:
Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA Univ Minnesota Minneapolis MN USA 55454 demiol, Minneapolis, MN 55454 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Oklahoma, Ctr Amer Indian Hlth Res, Oklahoma City, OK USA Univ Oklahoma Oklahoma City OK USA ndian Hlth Res, Oklahoma City, OK USA Univ Pittsburgh, Sch Med, Div Geriatr Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA d, Div Geriatr Med, Pittsburgh, PA USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USAJohns Hopkins Univ Baltimore MD USA h, Dept Epidemiol, Baltimore, MD USA Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 , Sch Med, Dept Med, Boston, MA 02118 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 163, anno: 2001,
pagine: 19 - 25
SICI:
1073-449X(200101)163:1<19:SBACDC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ACUTE MYOCARDIAL-INFARCTION; APNEA SYNDROME; URINARY CATECHOLAMINES; SYMPATHETIC ACTIVITY; CIRCADIAN VARIATION; RISK FACTOR; STROKE; HYPERTENSION; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Shahar, E Univ Minnesota, Sch Publ Hlth, Div Epidemiol, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA Univ Minnesota 1300 S 2nd St,Suite 300 Minneapolis MN USA 55454
Citazione:
E. Shahar et al., "Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study", AM J R CRIT, 163(1), 2001, pp. 19-25

Abstract

Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep-disordered breathing and self-reported CVD in 6,424 free-living individuals who underwent overnight, unattended polysomnography at home. Sleep-disordered breathing was quantified by the apnea-hypopnea index (AHI)-the average number hypopneas per hour of sleep. Mild to moderate disordered breathing during sleep was highly prevalent in thesample (median AHI: 4.4; interquartile range: 1.3 to 11.0). A total of 1,023 participants (16%) reported at least one manifestation of CVD (myocardial infarction, angina, coronary revascularization procedure, heart failure, or stroke). The multivariable-adjusted relative odds (95% CI) of prevalent CVD for the second, third, and fourth quartiles of the AHI (versus the first) were 0.98 (0.77-1.24), 1.28 (1.02-1.61), and 1.42 (1.13-1.78), respectively. Sleep-disordered breathing was associated more strongly with self-reported heart failure and stroke than with self-reported coronary heart disease: the relative odds (95% CI) of heart failure, stroke, and coronary heart disease (upper versus lower AHI quartile) were 2.38 (1.22-4.62), 1.58 (1.02-2.46), and 1.27 (0.99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated.

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Documento generato il 24/11/20 alle ore 22:50:28