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Titolo:
Septic shock and acute lung injury in rabbits with peritonitis - Failure of the neutrophil response to localized infection
Autore:
Matute-Bello, G; Frevert, CW; Kajikawa, O; Skerrett, SJ; Goodman, RB; Park, DR; Martin, TR;
Indirizzi:
Univ Washington, Med Res Serv, Vet Affairs Puget Sound Hlth Care Syst, SchMed, Seattle, WA USA Univ Washington Seattle WA USA d Hlth Care Syst, SchMed, Seattle, WA USA Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Med, Dept Med, Seattle, WA 98195 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 163, anno: 2001,
pagine: 234 - 243
SICI:
1073-449X(200101)163:1<234:SSAALI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; TUMOR-NECROSIS-FACTOR; SEVERE SEPSIS; INFLAMMATORY RESPONSE; MULTICENTER TRIAL; FUSION PROTEIN; COLI PNEUMONIA; CANINE MODEL; BACTEREMIA; COMPARTMENTALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, TR Vet Adm Med Ctr, 151L,1660 S Columbian Way, Seattle, WA 98108 USA Vet Adm Med Ctr 151L,1660 S Columbian Way Seattle WA USA 98108
Citazione:
G. Matute-Bello et al., "Septic shock and acute lung injury in rabbits with peritonitis - Failure of the neutrophil response to localized infection", AM J R CRIT, 163(1), 2001, pp. 234-243

Abstract

The major goal of this study was to investigate the mechanisms that link the host response to a local infection in the peritoneal cavity with the development of sepsis and lung injury. Rabbits were infected by intraperitoneal inoculation of fibrin clots containing Es-cherichia coil at 10(8), 10(9),or 10(10) cfu/clot. Physiologic, bacteriologic, and inflammatory responseswere monitored, and the lungs were examined postmortem. At a dose of 108 cfu/clot the animals had resolving infection, and a dose of 109 cfu/clot resulted in persistent infection at 24 h, with minimal systemic manifestations. In contrast, inoculation of 10(10) cfu/clot resulted in rapidly lethal local infection, with septic shock and lung injury. The onset of septic shockwas associated with a paradoxical lack of identifiable polymorphonuclear leukocytes (PMN; neutrophils) in the peritoneal cavity. The absence of PMN in the peritoneum was due in part to lysis of intraperitoneal PMN, because the peritoneal fluids contained free myeloperoxidase and induced rapid deathof normal rabbit PMN in vitro. Although most animals became bacteremic, only those with a severe systemic inflammation response developed lung injury. These data show that control of an infection in the first compartment in which bacteria enter the host is a critical determinant of the systemic response. Above a threshold dose of bacteria, failure of the local neutrophil response is a key mechanism associated with deleterious systemic responses. Bacteremia alone is not sufficient to cause lung injury. Lung injury occurs only in the setting of a severe systemic inflammatory response and an inadequate leukocyte response at the primary site of infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:28:30