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Titolo:
Propofol versus midazolam regarding their antioxidant activities
Autore:
Tsuchiya, M; Asada, A; Maeda, K; Ueda, Y; Sato, EF; Shindo, M; Inoue, M;
Indirizzi:
Osaka City Univ, Sch Med, Dept Biochem, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 chem, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Anesthesiol & Intens Care Med, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Med, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 163, anno: 2001,
pagine: 26 - 31
SICI:
1073-449X(200101)163:1<26:PVMRTA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; FREE-RADICAL SCAVENGER; ALPHA-TOCOPHEROL; LIPID-PEROXIDATION; DIHYDROLIPOIC ACID; VITAMIN-E; IN-VITRO; OXIDATION; MEMBRANE; PHOSPHATIDYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuchiya, M Osaka City Univ, Sch Med, Dept Biochem, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 5, Japan
Citazione:
M. Tsuchiya et al., "Propofol versus midazolam regarding their antioxidant activities", AM J R CRIT, 163(1), 2001, pp. 26-31

Abstract

Propofol and midazolam are commonly used as sedatives for critically ill patients. These patients usually suffer from the pathologic effects of oxidative stress, predominantly caused by an imbalance between the generation ofreactive oxygen species and the antioxidant defense system. Therefore, theantioxidant activities of propofol and midazolam may be of clinical importance. We investigated the activities of these two sedatives against hydrophilic or lipophilic peroxyl radicals in a homogeneous solution and in the presence of erythrocyte membranes. A chemical analysis of the homogeneous solution revealed that propofol efficiently scavenged hydrophilic peroxyl radicals (50% inhibitory concentration [IC50] = 1.3 x 10(-4) M), whereas midazolam efficiently scavenged lipophilic radicals (IC50 = 1.5 x 10(-5) M). Further, in membrane systems, propofol inhibited the oxidative damage induced by either hydrophilic or lipophilic radicals (IC50 = 1.5 x 10-5 M for hydrophilic radicals and IC50 = 3.0 x 10(-4) M for lipophilic radicals), whereas midazolam did very little. In previous studies, we demonstrated that antioxidant activity is highly affected by the location and properties of the reaction site. The discrepancy in antioxidant activity between a homogeneous condition and in the presence of membranes can be well explained by this concept, and again emphasizes the importance of membranes in determining antioxidant activity. To further understand the biologic significance of these antioxidant properties, the effect of the two agents on endothelium-dependent relaxation was studied. Application of oxidative stress to aortic rings by treating them with peroxyl radicals led to a significant blockade of acetylcholine-induced relaxation after submaximal contraction with phenylephrine. Propofol pretreatment greatly attenuated the impairment in comparison with midazolam, which agrees with the concept of antioxidant activity in the presence of membranes. The results of the present study suggest that propofol has a greater potential to reduce oxidative stress than midazolam.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:33:28