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Titolo:
Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids
Autore:
Cavicchioli, P; Zimmermann, LJI; Cogo, PE; Badon, T; Giordano, G; Torresin, M; Zacchello, F; Carnielli, VP;
Indirizzi:
Univ Padua, Dept Pediat, Padua, Italy Univ Padua Padua ItalyUniv Padua, Dept Pediat, Padua, Italy Erasmus Univ, Dept Pediat, Rotterdam, Netherlands Erasmus Univ RotterdamNetherlands Dept Pediat, Rotterdam, Netherlands Inst Child Hlth, London, England Inst Child Hlth London EnglandInst Child Hlth, London, England Great Ormond St Hosp Children, Inst Child Hlth, MRC, CNRC, London WC1N 1EH, England Great Ormond St Hosp Children London England WC1N 1EH WC1N 1EH, England
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 163, anno: 2001,
pagine: 55 - 60
SICI:
1073-449X(200101)163:1<55:ESTIPI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRITICALLY ILL INFANTS; RAT LUNG; VENTILATED LAMBS; KETONE-BODIES; NEWBORN RATS; FATTY-ACID; II CELLS; PHOSPHATIDYLCHOLINE; METABOLISM; FETAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Carnielli, VP Great Ormond St Hosp Children, Inst Child Hlth, MRC, CNRC, 30 Guilford St,Room W4-03, London WC1N 1EH, England Great Ormond St Hosp Children 30 Guilford St,Room W4-03 London England WC1N 1EH
Citazione:
P. Cavicchioli et al., "Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids", AM J R CRIT, 163(1), 2001, pp. 55-60

Abstract

We studied surfactant kinetics on Day 1 of life in 11 preterm infants on mechanical ventilation by infusing stable isotope labeled palmitic (PA) and linoleic acid (LLA). Six infants received exogenous surfactant for the treatment of respiratory distress syndrome (RDS) and five did not meet treatment criteria because of minimal or no disease. The isotopic enrichment of plasma free PA and LLA and of surfactant phosphatidylcholine PA (PC-PA) and LLA (PC-LLA) from tracheal aspirates was measured by mass spectrometry. Significant isotopic enrichment could be measured in PC-PA and PC-LLA from all patients. The fractional synthesis rate (FSR) of PCLLA was higher than that of PC-PA (22.7 +/- 15.9 versus 12.1 +/- 7.7% per day, p = 0.018). Half-life(HL) of PC-PA was longer than that of PC-LLA (94.7 +/- 18.8 versus 46.6 +/- 32.6 h, p = 0.028). Patients who received exogenous surfactant had longersecretion times (ST) and delayed peak times (PK) but FSR and HL were unaffected. We concluded that: (7) surfactant kinetics can be measured in preterm infants with stable isotope labeled lipids; (2) surfactant FSR and HL calculated with PA and LLA gave different results; (3) patients treated with exogenous surfactant had similar FSRs compared with the nontreated subjects but had longer ST and delayed PK; (4) FSR from plasma free fatty acids (present study) was higher than that from plasma glucose in our previous work (Bunt JEH, Zimmermann LJI, Wattimena D, van Beek R, Sauer PJJ, Carnielli vp. Am J Respir Crit Core Med 1998;157:810-814) in a comparable population of preterm infants with RDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:16:37