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Titolo:
Efficacy and safety of vitamin D-3 intake exceeding the lowest observed adverse effect level
Autore:
Vieth, R; Chan, PCR; MacFarlane, GD;
Indirizzi:
Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada Mt SinaiHosp Toronto ON Canada M5G 1X5 Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 b Med, Toronto, ON M5G 1X5, Canada DiaSorin Inc, Stillwater, MN USA DiaSorin Inc Stillwater MN USADiaSorin Inc, Stillwater, MN USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 2, volume: 73, anno: 2001,
pagine: 288 - 294
SICI:
0002-9165(200102)73:2<288:EASOVD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CALCIUM EXCRETION; 25-HYDROXYVITAMIN-D CONCENTRATIONS; HYPOVITAMINOSIS-D; D SUPPLEMENTATION; CREATININE RATIO; D INTOXICATION; WOMEN; SERUM; METABOLITES; PREVALENCE;
Keywords:
cholecalciferol; calcidiol; vitamin D-3; hypercalciuria; toxicity; lowest observed adverse effect level; LOAEL; efficacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Vieth, R Mt Sinai Hosp, Dept Pathol & Lab Med, 600 Univ Ave, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 1X5, Canada
Citazione:
R. Vieth et al., "Efficacy and safety of vitamin D-3 intake exceeding the lowest observed adverse effect level", AM J CLIN N, 73(2), 2001, pp. 288-294

Abstract

Background: The Food and Nutrition Board of the National Academy of Sciences states that 95 mug vitamin D/d is the lowest observed adverse effect level (LOAEL). Objective: Our objective was to assess the efficacy and safety of prolonged vitamin D-3 intakes of 25 and 100 mug (1000 and 4000 IU)/d. Efficacy was based on the lowest serum 25-hydroxyvitamin D [25(OH)D] concentration achieved by subjects taking vitamin D-3; potential toxicity was monitored by measuring serum calcium concentrations and by calculating urinary calcium-creatinine ratios. Design: Healthy men and women (n = 61) aged 41 +/- 9 y ((x) over bar +/- SD) were randomly assigned to receive either 25 or 100 mug vitamin D-3/d for2-5 mo, starting between January and February. Serum 25(OK)D was measured by radioimmunoassay. Results: Baseline serum 25(OH)D was 40.7 +/- 15.4 nmol/L ((x) over bar +/-SD). From 3 mo on, serum 25(OH)D plateaued at 68.7 +/- 16.9 nmol/L in the 25-mug/d group and at 96.4 +/- 14.6 nmol/L in the 100-mug/d group. Summertime serum 25(OH)D concentrations in 25 comparable subjects not taking vitamin D-3 were 46.7 +/- 17.8 nmol/L. The minimum and maximum plateau serum 25(OH)D concentrations in subjects taking 25 and 100 mug vitamin D-3/d were 40 and 100 nmol/L and 69 and 125 nmol/L, respectively. Serum calcium and urinary calcium excretion did not change significantly at either dosage during the study. Conclusions: The 100-mug/d dosage of vitamin D-3 effectively increased 25(OH)D to high-normal concentrations in practically all adults and serum 25(OH)D remained within the physiologic range; therefore, we consider 100 mug vitamin D-3/d to be a safe intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:33:18