Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interleukin-4-positive mast cells are highly associated with the extent ofimmediate allergic wheal reaction in the skin
Autore:
Saarinen, JV; Harvima, RJ; Horsmanheimo, M; Harvima, IT; Naukkarinen, A;
Indirizzi:
Kuopio Univ Hosp, Dept Dermatol, Kuopio 70211, Finland Kuopio Univ Hosp Kuopio Finland 70211 pt Dermatol, Kuopio 70211, Finland Kuopio Univ Hosp, Dept Clin Pathol, Kuopio 70211, Finland Kuopio Univ Hosp Kuopio Finland 70211 Clin Pathol, Kuopio 70211, Finland
Titolo Testata:
ALLERGY
fascicolo: 1, volume: 56, anno: 2001,
pagine: 58 - 64
SICI:
0105-4538(200101)56:1<58:IMCAHA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEASE INHIBITORS; HISTAMINE-RELEASE; ATOPIC-DERMATITIS; INTERFERON-GAMMA; MEDIATOR RELEASE; I EXPRESSION; SUBSTANCE-P; CHYMASE; TRYPTASE; IL-4;
Keywords:
cytokine; mediator; prick test; protease; type I allergy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Harvima, RJ Kuopio Univ Hosp, Dept Dermatol, POB 1777, Kuopio 70211, Finland Kuopio Univ Hosp POB 1777 Kuopio Finland 70211 70211, Finland
Citazione:
J.V. Saarinen et al., "Interleukin-4-positive mast cells are highly associated with the extent ofimmediate allergic wheal reaction in the skin", ALLERGY, 56(1), 2001, pp. 58-64

Abstract

Background: In addition to histamine, mast cells contain other potent mediators which can contribute to the allergic wheal reaction in the skin. Methods: To study the association of tryptase-, chymase-, and interleukin-4 (IL-4)-positive mast cells with the size of the prick-test wheal reaction, 50 sensitive atopic subjects were prick-tested with the cow-dander allergen on the forearm skin, and the wheal area was measured. A corresponding site of intact healthy-looking skin was biopsied and examined enzyme-histochemically for tryptase and chymase. A double-staining method was used to demonstrate the immunoreactivity of IL-4 and chymase inhibitors (alpha (1)-proteinase inhibitor and alpha (1)-antichymotrypsin) in mast cells. The levels of total and cow-specific immunoglobulin E (IgE) were measured in serum. Results: The number of tryptase- and chymase-positive mast cells or those containing chymase inhibitors revealed no correlation with the wheal reaction. In contrast, both the percentage and the number of IL-4-positive mast cells showed significant positive correlation with the wheal size per se (P < 0.0001), as well as with the ratio of the wheal size by cow allergen to that by histamine control (P < 0.003). In addition. tryptase-, chymase-, andIL-3-positive mast cells correlated with total IgE, but not with specific IgE, levels, and they showed no relation to the clinical manifestation of atopic disease, asthma or atopic dermatitis. Conclusions: The novel finding was that IL-4-positive, but not tryptase- and chymase-positive, mast cells are intimately associated with the extent of the prick-test wheal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:29:25