Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Extraversion - Interaction between D2 dopamine receptor polymorphisms and parental alcoholism
Autore:
Ozkaragoz, T; Noble, EP;
Indirizzi:
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
ALCOHOL
fascicolo: 3, volume: 22, anno: 2000,
pagine: 139 - 146
SICI:
0741-8329(200011)22:3<139:E-IBDD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXON-III POLYMORPHISM; NOVELTY-SEEKING; PERSONALITY-TRAITS; ALLELIC ASSOCIATION; HEALTHY-VOLUNTEERS; DRINKING BEHAVIOR; NO ASSOCIATION; SUBSTANCE USE; DRD2 LOCUS; A1 ALLELE;
Keywords:
sons of alcoholics; Junior Eysenck Personality Inventory; Extraversion; D2 and D4 dopamine receptor genes; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Noble, EP Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA Univ Calif Los Angeles 760 Westwood Plaza Los Angeles CA USA 90024
Citazione:
T. Ozkaragoz e E.P. Noble, "Extraversion - Interaction between D2 dopamine receptor polymorphisms and parental alcoholism", ALCOHOL, 22(3), 2000, pp. 139-146

Abstract

Both molecular genetic factors (the D2 dopamine receptor (DRD2) and the D4dopamine receptor (DRD4) polymorphisms) and environmental influences of living in an alcoholic or nonalcoholic home on the personality traits of Extraversion and Neuroticism were assessed in drug-naive, young adolescent boys. There were no significant main effects of genetic or environmental factors on either Neuroticism or Extraversion as measured by the Junior Eysenck Personality Inventory (JEPI). However, a significant interaction between DRD2 (but not DRD4) alleles and environmental variables was observed on Extraversion. Specifically, children with the minor alleles of the DRD2 gene showed a significantly greater Extraversion score when living in an alcoholic than in a nonalcoholic home. In contrast, children with the major alleles ofthe DRD2 gene showed a trend in the opposite direction. Although the results are preliminary and pending replication, they nevertheless provide the first report of a specific gene-environment interaction involving a human personality trait. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:25:56