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Titolo:
Muscle strength, functional mobility and vitamin D in older women
Autore:
Verhaar, HJJ; Samson, MM; Jansen, PAF; de Vreede, PL; Manten, JW; Duursma, SA;
Indirizzi:
Univ Utrecht, Ctr Med, Dept Geriatr, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
AGING-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 6, volume: 12, anno: 2000,
pagine: 455 - 460
SICI:
0394-9532(200012)12:6<455:MSFMAV>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
D METABOLITES; D DEFICIENCY; 1,25-DIHYDROXYVITAMIN-D3; POPULATION; WEAKNESS; TESTS; FRAIL;
Keywords:
muscle strength; older women; vitamin D deficiency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Verhaar, HJJ Univ Utrecht, Ctr Med, Dept Geriatr, POB 85500,Room W01-209, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500,Room W01-209 Utrecht Netherlands NL-3508 GA
Citazione:
H.J.J. Verhaar et al., "Muscle strength, functional mobility and vitamin D in older women", AGING-CLIN, 12(6), 2000, pp. 455-460

Abstract

Vitamin D deficiency may lead to loss of type II muscle fibres, and thereby to atrophy of proximal muscles with an increased risk of falling and bonefractures. The aim of the study was to determine if six months of vitamin D treatment (0.5 mug alphacalcidol) could positively influence values for muscle strength and functional mobility in vitamin D-deficient older women. Twenty-seven women entered the study which took place at a teaching hospital outpatient department. Ten vitamin D-deficient (serum 25(OH)D-3 < 20 nmol/L) older (> 70 years) women and 13 age-matched female subjects with normalvitamin D levels (serum 25(OH)D3 > 30 nmol/L) completed the study. Pre-andpost-treatment data were obtained for isometric knee extensor strength, handgrip strength and functional mobility (walking distance over 2 minutes and the timed "Up & Go" test). Six months of treatment with alphacalcidol ledto significant improvements (compared to the controls) in values of isometric knee extensor strength (left leg: 14.6%+/-5.7%, p=0.03; right leg: 11.5%+/-5.0%, p=0.02) (mean+/-SEM). The achievements in the timed "Up & Go" test and 2-minute walking test did not improve in the alphacalcidol group compared to the controls after 6 months. However, within the vitamin D-deficient group, 6 months of alphacalcidol treatment led to a significant increase in the walking distance over 2 minutes (increase from 137.6+/-12.6 to 151.3/-11.2 meters, p=0.03). The controls, with normal vitamin D levels, did not exhibit improvements in performance of any of the tests over a period of 6 months. Summarized, alphacalcidol seems to improve muscle strength and walking distance over 2 minutes in vitamin D-deficient older women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:13:30