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Titolo:
Incentive-sensitization and addiction
Autore:
Robinson, TE; Berridge, KC;
Indirizzi:
Univ Michigan, Dept Psychol, Biopsychol Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 hol Program, Ann Arbor, MI 48109 USA
Titolo Testata:
ADDICTION
fascicolo: 1, volume: 96, anno: 2001,
pagine: 103 - 114
SICI:
0965-2140(200101)96:1<103:IAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPEATED D-AMPHETAMINE; RAT NUCLEUS-ACCUMBENS; INDUCED BEHAVIORAL SENSITIZATION; DOPAMINE RELEASE; ENVIRONMENTAL STIMULI; METHAMPHETAMINE PSYCHOSIS; TEMPORAL CHARACTERISTICS; INTRAVENOUS AMPHETAMINE; ELECTRICAL-STIMULATION; REPEATED PRETREATMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, TE Univ Michigan, Dept Psychol, Biopsychol Program, 525 E Univ East Hall, AnnArbor, MI 48109 USA Univ Michigan 525 E Univ East Hall Ann Arbor MI USA 48109 USA
Citazione:
T.E. Robinson e K.C. Berridge, "Incentive-sensitization and addiction", ADDICTION, 96(1), 2001, pp. 103-114

Abstract

The question of addiction concerns the process by which drug-taking behavior, in certain individuals, evolves into compulsive patterns of drug-seeking and drug-taking behavior that rake place at the expense of most other activities, and the inability ro cease drug-taking, that is, the problem of relapse. In this paper we summarize one view of this process, the "incentive-sensitization" view, which we first proposed in 1993. Four major tenets of the incentive-sensitization view are discussed. These are: (1) potentially addictive drugs share the ability to alter brain organization; (2) the brain systems that are altered include there normally involved in the process of incentive motivation and reward; (3) the critical neuroadaptations for addiction render these brain reward systems hypersensitive ("sensitized") to drugs and drug-associated stimuli; and (4) the brain systems that are sensitized do nor mediate the pleasurable or euphoric effects of drugs (drug "liking"), but instead they mediate a subcomponent of reward we have termed incentive salience (drug "wanting").

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Documento generato il 04/04/20 alle ore 22:44:39