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Titolo:
Solitary peripapillary hemangioblastoma - A histopathological case report
Autore:
Joussen, AM; Kirchhof, B;
Indirizzi:
Rhein Westfal TH Aachen, Dept Ophthalmol, Aachen, Germany Rhein Westfal THAachen Aachen Germany Dept Ophthalmol, Aachen, Germany
Titolo Testata:
ACTA OPHTHALMOLOGICA SCANDINAVICA
fascicolo: 1, volume: 79, anno: 2001,
pagine: 83 - 87
SICI:
1395-3907(200102)79:1<83:SPH-AH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; HIPPEL-LINDAU-DISEASE; TUMOR-SUPPRESSOR GENE; CENTRAL NERVOUS-SYSTEM; STROMAL CELLS; FACTOR FAMILY; ANGIOGENESIS; MUTATION; ANGIOMA;
Keywords:
hemangioblastoma; peripapillary lesion; histology; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Joussen, AM Harvard Univ, Sch Med, Childrens Hosp, Surg Res Labs, Enders 1025,300 Longwood Ave, Boston, MA 02115 USA Harvard Univ Enders 1025,300 Longwood Ave Boston MA USA 02115
Citazione:
A.M. Joussen e B. Kirchhof, "Solitary peripapillary hemangioblastoma - A histopathological case report", ACT OPHTH S, 79(1), 2001, pp. 83-87

Abstract

Purpose: Hemangioblastomas are highly vascularized tumors of not well-defined histological origin. They are the most frequent manifestation of the von-Hippel-Lindau (VHL) disease, but also occur as sporadic non-hereditary tumors Much has been learned in the recent past about the genetic background,however, the cellular origin of the tumor is still not resolved,Methods: We report a rare case of sporadic peripapillary hemangioblastoma in a 58-year-old patient. Results: Histological examination demonstrated a highly vascularized tumorwith intercapillary stromal tells. The tumor did not invade the adjacent tissues. Surrounding retinal areas showed cystic and gliotic changes. Immunohistochemistry was unable to prove neuroglial origin of the stromal cells. Conclusion: Histological findings show similarities to the findings in cerebral hemangioblastomas. The tumor location in this case together with the known response of glial cells to VHL, might indicate their involvement in the pathogenesis of hemangioblastoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:35:55