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Titolo:
Borna disease virus: a mystery as an emerging zoonotic pathogen
Autore:
Richt, JA; Rott, R;
Indirizzi:
Inst Virol, D-35392 Giessen, Germany Inst Virol Giessen Germany D-35392Inst Virol, D-35392 Giessen, Germany
Titolo Testata:
VETERINARY JOURNAL
fascicolo: 1, volume: 161, anno: 2001,
pagine: 24 - 40
SICI:
1090-0233(200101)161:1<24:BDVAMA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; CHRONIC-FATIGUE-SYNDROME; MENTAL-HEALTH WORKERS; CLASS-II ANTIGEN; PSYCHIATRIC-PATIENTS; JAPANESE PATIENTS; NEUROPSYCHIATRIC DISORDERS; BEHAVIORAL ABNORMALITIES; NEUROLOGICAL DISORDERS; SCHIZOPHRENIC-PATIENTS;
Keywords:
Borna disease; pathogenesis; epizootiology; epidemiology; zoonosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
142
Recensione:
Indirizzi per estratti:
Indirizzo: Richt, JA Inst Virol, Frankfurterstr 107, D-35392 Giessen, Germany Inst Virol Frankfurterstr 107 Giessen Germany D-35392 , Germany
Citazione:
J.A. Richt e R. Rott, "Borna disease virus: a mystery as an emerging zoonotic pathogen", VET J, 161(1), 2001, pp. 24-40

Abstract

For Central European veterinarians, Borna disease (BD) has been known for a long time as a sporadically occurring, progressive viral polioencephalomyelitis predominantly affecting horses and sheep and-as discovered in the last decade-an increasing number of domestic and zoo animals. The aetiological agent, the Borna disease virus (BDV), a negative-sense, single-stranded RNA virus classified in the new virus family Bornaviridae within the order Mononegavirales, can induce severe clinical signs typically of a viral encephalitis with striking behavioural disturbances. After an incubation period lasting a few weeks to several months, BDV-infection causes locomotor and sensory dysfunctions followed by paralysis and death. Natural infections seem to be subclinical in most cases. BD received world-wide attention when it was reported that sera and/or cerebrospinal fluids from neuro psychiatric patients can contain BDV-specific antibodies. Since infected animals produce BDV-specific antibodies only after virus replication, it was assumed that the broad spectrum of BDV-susceptible species also includes man. However, reports describing the presence ofother BDV-markers, i.e. BDV-RNA or BDV-antigen, in peripheral blood leukocytes or brain tissue of neuro-psychiatric patients are highly controversialand, therefore, the role of BDV in human neuro-psychiatric disorders is questionable. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:11:09