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Titolo:
Serum levels of TCDD and dioxin-like chemicals in rhesus monkeys chronically exposed to dioxin: Correlation of increased serum PCB levels with endometriosis
Autore:
Rier, SE; Turner, WE; Martin, DC; Morris, R; Lucier, GW; Clark, GC;
Indirizzi:
Dartmouth Med Sch, Dept Physiol, Lebanon, NH 03756 USA Dartmouth Med Sch Lebanon NH USA 03756 ept Physiol, Lebanon, NH 03756 USA Ctr Dis Control & Prevent, US Publ Hlth Serv, Atlanta, GA 30341 USA Ctr Dis Control & Prevent Atlanta GA USA 30341 erv, Atlanta, GA 30341 USA Univ Tennessee, Dept Obstet & Gynecol, Memphis, TN 38103 USA Univ Tennessee Memphis TN USA 38103 stet & Gynecol, Memphis, TN 38103 USA NIEHS, Res Triangle Pk, NC 27709 USA NIEHS Res Triangle Pk NC USA 27709NIEHS, Res Triangle Pk, NC 27709 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 59, anno: 2001,
pagine: 147 - 159
SICI:
1096-6080(200101)59:1<147:SLOTAD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIBENZO-P-DIOXINS; TOXICOKINETIC MIXTURE INTERACTIONS; POLYCHLORINATED-BIPHENYLS PCBS; TOXIC EQUIVALENCY FACTORS; MACACA-MULATTA; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN TCDD; AROMATIC-HYDROCARBONS; VIETNAM VETERANS; ADIPOSE-TISSUE; RATS;
Keywords:
endometriosis; rhesus monkey; environmental toxicants; dioxin; TCDD; PCB; dioxin-like chemicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Rier, SE Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, B1100 Med Ctr N,Nashville, TN 37232 USA Vanderbilt Univ B1100 Med Ctr N Nashville TN USA 37232 37232 USA
Citazione:
S.E. Rier et al., "Serum levels of TCDD and dioxin-like chemicals in rhesus monkeys chronically exposed to dioxin: Correlation of increased serum PCB levels with endometriosis", TOXICOL SCI, 59(1), 2001, pp. 147-159

Abstract

Humans and animals are exposed daily to a complex mixture of polyhalogenated aromatic hydrocarbons (PHAHs). Previous work has shown that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with a dose-dependent increase in the incidence and severity of endometriosis in the rhesus monkey. Dioxin-like chemicals can also exert effects in combination with TCDD via the aryl hydrocarbon receptor. This study demonstrates that the serumlevels of TCDD and specific dioxin-like PHAH congeners were increased in TCDD-treated animals with endometriosis 13 years after the TCDD exposure. Nine TCDD-exposed and 6 unexposed female rhesus monkeys were evaluated for serum content of relevant compounds and for endometriosis by surgical laparoscopy. Additional studies were done on 4 animals that died 7 to 11 years after exposure to TCDD and 4 lead-treated animals with no history of PHAH treatment. For TCDD-exposed and unexposed animals, TCDD exposure correlated with an increased serum TCDD concentration. Furthermore, TCDD exposure and an elevated serum TCDD concentration were associated with increased serum levels of triglycerides, 1,2,3,6,7,8-hexachlorodibenzofuran, 3,3',4,4'-tetrachlorobiphenyl (TCB) and 3,3'4,4',5-pentachlorobiphenyl (PnCB). Importantly, the animals with elevated serum levels of 3,3',4,4'-TCB, 3,3',4,4',5-PnCB and an increased total serum TEQ had a high prevalence of endometriosis, and the severity of disease correlated with the serum concentration of 3,3',4,4'-TCB. Increased serum concentrations of coplanar PCBs were also present inlead-treated animals. Implications of these findings for human health and the prevalence of endometriosis in humans will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:18:34