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Titolo:
The toxicology of inhaled nitric oxide
Autore:
Weinberger, B; Laskin, DL; Heck, DE; Laskin, JD;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat Neonatol, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA08854 scataway, NJ 08854 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Environm & Community Med, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA Rutgers State Univ, Dept Pharmacol & Toxicol, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 icol, Piscataway, NJ 08854 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 59, anno: 2001,
pagine: 5 - 16
SICI:
1096-6080(200101)59:1<5:TTOINO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; SMOOTH-MUSCLE CELLS; HYPOXEMIC RESPIRATORY-FAILURE; SURFACTANT PROTEIN-A; ACUTE LUNG INJURY; NITROGEN-DIOXIDE; BLEEDING-TIME; DNA-DAMAGE; PLATELET-AGGREGATION; IN-VITRO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberger, B St Peters Univ Hosp, Div Neonatol, 254 Easton Ave, New Brunswick, NJ 08903USA St Peters Univ Hosp 254 Easton Ave New Brunswick NJ USA 08903
Citazione:
B. Weinberger et al., "The toxicology of inhaled nitric oxide", TOXICOL SCI, 59(1), 2001, pp. 5-16

Abstract

Inhaled nitric oxide is a targeted pulmonary vasodilator that improves clinical outcomes for newborn patients with persistent pulmonary hypertension of the newborn, and may be effective in treating some premature patients with acute respiratory distress syndrome or lung disease of prematurity. Nitric oxide is now recognized as playing an important role in the regulation of diverse physiological processes. However, the pharmacological properties of inhaled nitric oxide are not easy to separate from its toxicological effects. For example, the intended effect of inhaled nitric oxide, vasodilation in the lung, is mediated, in part, by increased cellular cyclic GMP (cGMP). However, increased cGMP can also interfere with normal cellular proliferation. Nitric oxide has also been shown to cause DNA strand breaks and/or base alterations that are potentially mutagenic, Inhaled nitric oxide can rapidly react with oxygen in the lung to form nitrogen dioxide, which is a potent pulmonary irritant, Nitric oxide also reacts with superoxide anion to form peroxynitrite, a cytotoxic oxidant that can interfere with surfactant functioning. The overall effect of inhaled nitric oxide in potentiating or attenuating inflammation and oxidative damage in diseased lung is dependenton the dose administered, Furthermore, despite rapid inactivation by circulating hemoglobin, inhaled nitric oxide exerts effects outside the lung, including blocking platelet aggregation, causing methemoglobinemia, and possibly inducing extrapulmonary vasodilation. The toxicology of inhaled nitric oxide is not completely understood and must be considered in the design of protocols for its safe and effective clinical use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:55:56