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Titolo:
Genes regulating embryonic and fetal survival
Autore:
Cross, JC;
Indirizzi:
Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 Biol, Calgary, AB T2N 4N1, Canada
Titolo Testata:
THERIOGENOLOGY
fascicolo: 1, volume: 55, anno: 2001,
pagine: 193 - 207
SICI:
0093-691X(20010101)55:1<193:GREAFS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA INHIBITORY FACTOR; BHLH TRANSCRIPTION FACTOR; STEM-CELLS; TARGETED DISRUPTION; TROPHOBLAST CELLS; HEART DEVELOPMENT; DEFICIENT MICE; BLASTOCYST IMPLANTATION; CARDIAC MORPHOGENESIS; PLACENTAL DEVELOPMENT;
Keywords:
embryo; cardiovascular; gene; implantation; placenta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Cross, JC Univ Calgary, Fac Med, Dept Biochem & Mol Biol, HSC Room 2279,3330 Hosp DrNW, Calgary, AB T2N 4N1, Canada Univ Calgary HSC Room 2279,3330 Hosp Dr NW Calgary AB Canada T2N 4N1
Citazione:
J.C. Cross, "Genes regulating embryonic and fetal survival", THERIOGENOL, 55(1), 2001, pp. 193-207

Abstract

Embryonic mortality in both farm animals and humans occurs most frequentlyduring the first few weeks after conception. It can be attributed to abnormalities in the earliest developmental processes during embryogenesis that include implantation, maternal recognition of pregnancy, and formation of the placenta and cardiovascular system. The molecular mechanisms that are essential for all of these early processes are being elucidated at a rapid pace using transgenic and gene knockout approaches in mice. Two important general conclusions have emerged from this work. First, placental defects can occur by a number of different molecular mechanisms and can result from defects in the development or function of its trophoblast, mesenchymal or vascular components. Second, placental and cardiovascular functions are intimately linked. Cells of the placenta, for example, produce hormones that have profound effects on maternal and fetal cardiac and vascular function. In addition, development of the two is linked mechanistically through the use ofsome genes that are essential for development of both. Understanding the molecular basis of these processes should help to address the major limits to the success of embryo transfer, IVF and embryo cloning practices in livestock species. (C) 2000 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:24:05