Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Spectral changes in systemic arterial pressure signals during acute mevinphos intoxication in the rat
Autore:
Yen, DHT; Yen, JC; Len, WB; Wang, LM; Lee, CH; Chan, SHH;
Indirizzi:
Natl Sun Yat Sen Univ, Ctr Neurosci, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ Kaohsiung Taiwan 80424 ci, Kaohsiung 80424, Taiwan Vet Gen Hosp Taipei, Dept Emergency Med, Taipei, Taiwan Vet Gen Hosp Taipei Taipei Taiwan i, Dept Emergency Med, Taipei, Taiwan Natl Yang Ming Univ, Dept Pharmacol, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Dept Pharmacol, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Inst Clin Med, Taipei 112, Taiwan Chang Gung Coll Nursing, Dept Biomed Sci, Taoyuan, Taiwan Chang Gung Coll Nursing Taoyuan Taiwan Dept Biomed Sci, Taoyuan, Taiwan
Titolo Testata:
SHOCK
fascicolo: 1, volume: 15, anno: 2001,
pagine: 35 - 41
SICI:
1073-2322(200101)15:1<35:SCISAP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; CENTRAL VENOUS-PRESSURE; BLOOD-PRESSURE; HEART-RATE; CHOLINERGIC MECHANISMS; CARDIOVASCULAR CONTROL; MUSCARINIC RECEPTORS; NERVOUS-SYSTEM; CONSCIOUS RATS; ORGANOPHOSPHATE;
Keywords:
organophosphate poisoning; autonomic cardiovascular regulation; sympathetic vasomotor tone; nucleus reticularis ventrolateralis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, SHH Natl Sun Yat Sen Univ, Ctr Neurosci, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ Kaohsiung Taiwan 80424 ung 80424, Taiwan
Citazione:
D.H.T. Yen et al., "Spectral changes in systemic arterial pressure signals during acute mevinphos intoxication in the rat", SHOCK, 15(1), 2001, pp. 35-41

Abstract

We investigated the cardiovascular consequences of acute intoxication by the organophosphate poison, mevinphos (Mev), and delineated the underlying mechanism. Based on on-line power spectral analysis of systemic arterial pressure (SAP) signals in rats anesthetized and maintained by propofol, we identified two distinct phases after intravenous administration of Mev (160 or320 mug/kg). Phase I was characterized by transient hypertension and mild tachycardia, concurrent with an increase in the very high-frequency (BVHF; 5-9 Hz), high-frequency (BHF; 0.8-2.4 Hz), low-frequency (BLF; 0.25-0.8 Hz),and very few-frequency (BVLF; 0-0.25 Hz) components of SAP signals. Phase Ii exhibited significant hypotension, a reversal of the BVHF and BVLF powerto control levels, and further reduction in the power density of both BHF and ELF components to below baseline, Microinjection of Mev (2 mug) into the bilateral nucleus reticularis ventrolateralis (NRVL), the medullary origin of sympathetic neurogenic vasomotor tone, essentially duplicated those phasic cardiovascular changes. Similarly, sympathoexcitatory NRVL neurons exhibited respectively an elevation and a decline in their spontaneous activities during Phase I and Phase II Mev intoxication. We conclude that the progressive accumulation of acety[choline over time induced by a direct inhibition of Mev on cholinesterase in the NRVL may be responsible for the phasic changes in cardiovascular events over the course of acute Mev intoxication. Whereas the initial amount of acetylcholine is excitatory to NRVL neurons,overstimulation by the amassed acetylcholine results instead of an inhibitory action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:05:40