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Titolo:
Decrease in immune activation in HIV-infected patients treated with highlyactive antiretroviral therapy correlates with the function of hematopoietic progenitor cells and the number of naive CD4(+) cells
Autore:
Nielsen, SD; Sorensen, TU; Ersboll, AK; Ngo, N; Mathiesen, L; Nielsen, JO; Hansen, JES;
Indirizzi:
Hvidovre Hosp, Dept Infect Dis, DK-2650 Hvidovre, Denmark Hvidovre Hosp Hvidovre Denmark DK-2650 ct Dis, DK-2650 Hvidovre, Denmark Royal Vet & Agr Univ, Dept Anim Sci & Anim Hlth, DK-1870 Frederiksberg C, Denmark Royal Vet & Agr Univ Frederiksberg Denmark C 70 Frederiksberg C, Denmark
Titolo Testata:
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
fascicolo: 6, volume: 32, anno: 2000,
pagine: 597 - 603
SICI:
0036-5548(2000)32:6<597:DIIAIH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD8(+) T-CELLS; IMMUNODEFICIENCY-VIRUS TYPE-1; BLOOD MONONUCLEAR-CELLS; CD38 ANTIGEN EXPRESSION; LYMPHOCYTE-ACTIVATION; RNA LEVELS; DISEASE PROGRESSION; PROTEASE INHIBITOR; PROGNOSTIC VALUE; FOLLOW-UP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nielsen, SD Hvidovre Hosp, Dept Infect Dis, DK-2650 Hvidovre, Denmark Hvidovre Hosp Hvidovre Denmark DK-2650 650 Hvidovre, Denmark
Citazione:
S.D. Nielsen et al., "Decrease in immune activation in HIV-infected patients treated with highlyactive antiretroviral therapy correlates with the function of hematopoietic progenitor cells and the number of naive CD4(+) cells", SC J IN DIS, 32(6), 2000, pp. 597-603

Abstract

This study was conducted to determine the impact of immune activation, cytokine production and apoptosis on the naive CD4(+) cell count and the function of hematopoietic progenitor cells during the initial phase of highly active antiretroviral therapy (HAART). Blood samples from 11 HIV-infected patients were collected prior to HAART and after 4 and 12 weeks of therapy. Flow cytometry mas used to determine the naive CD4(+) count and activated T cells. The cloning efficiency of progenitor cells was determined using a colony-forming cells assay. Finally, apoptosis and cytokine production were determined. During the study period, the naive CD4(+) count and the cloning efficiency increased significantly. Immune activation was found in HIV-infected patients and decreased during HAART. The level of immune activation correlated negatively with both the naive CD4(+) count and the function of progenitor cells. A negative correlation was found between apoptosis and the naive CD4(+) count. Alterations in cytokine production during HAART or correlation between cytokine production and the naive CD4(+) count or the cloning efficiency of progenitor cells were not detected. In conclusion, immune activation in HIV-infected patients treated with HAART is inversely correlated with the function of progenitor cells and the naive CD4(+) count.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:58:51