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Titolo:
Disease outcome in inflammatory bowel disease: Mortality, morbidity and therapeutic management of a 796-person inception cohort in the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD)
Autore:
Witte, J; Shivananda, S; Lennard-Jones, JE; Beltrami, M; Politi, P; Bonanomi, C; Tsianos, EV; Mouzas, I; Schulz, TB; Monteiro, E; Clofent, J; Odes, S; Limonard, CB; Stockbrugger, RW; Russel, MG;
Indirizzi:
Univ Maastricht, Dept Gastroenterol, Ctr Data & Informat Management, Memic, NL-6202 AZ Maastricht, Netherlands Univ Maastricht Maastricht Netherlands NL-6202 AZ aastricht, Netherlands Univ Hosp Maastricht, Dept Gastroenterol, Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands ol, Maastricht, Netherlands St Marks Hosp, Dept Gastroenterol, Harrow, Middx, England St Marks Hosp Harrow Middx England Gastroenterol, Harrow, Middx, England Dept Gastroenterol, Reggio Emilia, Italy Dept Gastroenterol Reggio Emilia Italy troenterol, Reggio Emilia, Italy Dept Gastroenterol, Cremona, Italy Dept Gastroenterol Cremona ItalyDept Gastroenterol, Cremona, Italy Policlin Careggi, Dept Gastroenterol, Florence, Italy Policlin Careggi Florence Italy gi, Dept Gastroenterol, Florence, Italy Univ Ioannina, Dept Internal Med, GR-45110 Ioannina, Greece Univ IoanninaIoannina Greece GR-45110 al Med, GR-45110 Ioannina, Greece Univ Ioannina, Dept Gastroenterol, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 nterol, GR-45110 Ioannina, Greece Univ Crete, Heraklion, Greece Univ Crete Heraklion GreeceUniv Crete, Heraklion, Greece Aust Agder Cent Hosp, Dept Med, Arendal, Norway Aust Agder Cent Hosp Arendal Norway ent Hosp, Dept Med, Arendal, Norway Hosp Univ Santa Maria, Dept Gastroenterol, Lisbon, Portugal Hosp Univ Santa Maria Lisbon Portugal t Gastroenterol, Lisbon, Portugal Meixoeiro Hosp, Dept Gastroenterol, Vigo, Spain Meixoeiro Hosp Vigo Spain ixoeiro Hosp, Dept Gastroenterol, Vigo, Spain Proviso Hosp, Dept Gastroenterol, Vigo, Spain Proviso Hosp Vigo SpainProviso Hosp, Dept Gastroenterol, Vigo, Spain Xeral Hosp, Dept Gastroenterol, Vigo, Spain Xeral Hosp Vigo SpainXeral Hosp, Dept Gastroenterol, Vigo, Spain Soroka Univ Hosp, Dept Gastroenterol, Beer Sheva, Israel Soroka Univ HospBeer Sheva Israel pt Gastroenterol, Beer Sheva, Israel
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 12, volume: 35, anno: 2000,
pagine: 1272 - 1277
SICI:
0036-5521(200012)35:12<1272:DOIIBD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULCERATIVE-COLITIS; CROHNS-DISEASE; CIGARETTE-SMOKING; NATURAL-HISTORY; RISK-FACTORS; PREVALENCE; SOUTH; COMPLICATIONS; EPIDEMIOLOGY; COPENHAGEN;
Keywords:
colitis; Crohn disease; epidemiology; inflammatory bowel diseases; outcome assessment (health care); therapy; ulcerative;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Russel, MG Univ Maastricht, Dept Gastroenterol, Ctr Data & Informat Management, Memic, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ nds
Citazione:
J. Witte et al., "Disease outcome in inflammatory bowel disease: Mortality, morbidity and therapeutic management of a 796-person inception cohort in the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD)", SC J GASTR, 35(12), 2000, pp. 1272-1277

Abstract

Background: The course of inflammatory bowel diseases (IBD) has mainly been studied using different methods in single patient cohorts. The aim of thepresent study was to assess clinical aspects of disease outcome in a population-based cohort of IBD patients over a 3-year period in multiple centresacross Europe. Methods: A total of 796 patients with LED diagnosed in 10 centres between October 1991 and October 1993, registered at the EC IBD study centre (98% of the original cohort), participated in the study. Investigators filled out a standard follow-up form containing questions on the method of follow-up, vital status of the patient, change in diagnosis, extraintestinal manifestations, medical and surgical treatment: and physician's global assessment of disease activity. Results: Complete relief of the complaints was reported in 255 (48%) patients with ulcerative colitis (UC), 9 (50%)with indeterminate colitis (IC), but only in 87 (35%) of patients with Crohn disease (CD). Improvement was reported in 195 (37%) patients with UC, 113 (45%) with CD and 6 (33%) with IC. During the 4-year follow-up period, 23patients died (14 UC, 8 CD, and 1 IC). The mean age at death was 69.3 years (s, 14.9 years). The deaths of three patients were recorded as directly due to PBD. Conclusions: With the present approach to therapeutic managementthe short-term outcome of patients with IBD seems to be favourable in 10 medical centres in the north and south of Europe. However, more detailed studies including both objective and subjective measures are necessary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:15:24