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Titolo:
Induction of micronuclei formation in preimplantation mouse embryos after maternal treatment with 2-bromopropane
Autore:
Ishikawa, H; Tian, Y; Yamauchi, T;
Indirizzi:
Mie Univ, Sch Med, Dept Publ Hlth, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 d, Dept Publ Hlth, Tsu, Mie 5148507, Japan
Titolo Testata:
REPRODUCTIVE TOXICOLOGY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 81 - 85
SICI:
0890-6238(200101/02)15:1<81:IOMFIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME-ABERRATIONS; 2-CELL EMBRYOS; BONE-MARROW; GERM-CELLS; RATS; EXPOSURE; TOXICITY; ZYGOTES; IMPLANTATION; IRRADIATION;
Keywords:
2-bromopropane; cell number; embryotoxicity; mice; micronuclei; preimplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ishikawa, H Mie Univ, Sch Med, Dept Publ Hlth, 2-174 Edobashi, Tsu, Mie 5148507, Japan Mie Univ 2-174 Edobashi Tsu Mie Japan 5148507 e 5148507, Japan
Citazione:
H. Ishikawa et al., "Induction of micronuclei formation in preimplantation mouse embryos after maternal treatment with 2-bromopropane", REPROD TOX, 15(1), 2001, pp. 81-85

Abstract

We examined effects of 2-bromopropane (2-BP), a chlorofluorocarbon replacement, on mouse embryonic mutagenicity. 2-BP was administered to pregnant mice intraperitoneally (i.p. ) (300, 600, 900, and 1800 mg/kg) during the early preimplantation period. On day 3 of gestation, micronuclei (MN) frequencyand embryo cell number were determined. 2-BP induced a dose-related significant increase in MN frequency and a treatment-related decrease in embryo cell number. Furthermore, the cell numbers were significantly smaller in theMN-positive embryos by two-way ANOVA taking it into account an interactiveeffect between 2-BP dose and the presence or absence of MN. A simultaneousdecrease in cell number and increase in MN frequency may reflect an embryonic developmental disadvantage resulting from maternal treatment with 2-BP. Further study is needed to establish how 2-BP contributes to postimplantation embryonic development. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:36:42