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Titolo:
Influence of secretin and L-NAME on vascular permeability in the coronary circulation of intact and diabetic rats
Autore:
Sitniewska, EM; Wisniewska, RJ;
Indirizzi:
Med Acad Bialystok, Dept Pharmacol, PL-15222 Bialystok, Poland Med Acad Bialystok Bialystok Poland PL-15222 PL-15222 Bialystok, Poland
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 3, volume: 96, anno: 2001,
pagine: 105 - 111
SICI:
0167-0115(20010112)96:3<105:IOSALO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; ENDOTHELIAL GROWTH-FACTOR; MODULATES MICROVASCULAR PERMEABILITY; NITRIC-OXIDE SYNTHESIS; STRUCTURAL REQUIREMENTS; RELAXING FACTOR; SMOOTH-MUSCLE; STREPTOZOTOCIN; PEPTIDE; SYSTEM;
Keywords:
diabetes; heart; nitric oxide; rats; secretin; vascular permeability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Wisniewska, RJ Med Acad Bialystok, Dept Pharmacol, 2C Mickiewicza, PL-15222 Bialystok, Poland Med Acad Bialystok 2C Mickiewicza Bialystok Poland PL-15222
Citazione:
E.M. Sitniewska e R.J. Wisniewska, "Influence of secretin and L-NAME on vascular permeability in the coronary circulation of intact and diabetic rats", REGUL PEPT, 96(3), 2001, pp. 105-111

Abstract

The permeability in the intact and diabetic rat coronary circulation afteradministration of secretin (3.0 mu mol/kg i.v.), an inhibitor of NOS (nitric oxide synthase), and L-NAME (N-G-nitro-L-arginine-methyl ester hydrochloride) (1 mg/kg i.v.), and both substances given together, were studied. To measure protein extravasation Evans blue dye was used as a marker of vascular permeability. The vascular permeability of the left ventricle did not differ in intact and diabetic rats. In the diabetes state increased permeability of atria was observed. Administration of secretin did not influence thecoronary vascular permeability in either the intact or the diabetic rats. L-NAME increased the atria permeability and did not change left ventricle permeability. In diabetes, injection of t-NAME caused a decrease in the permeability in both the atria and left ventricle. In intact rats secretin diminished the L-NAME effect in the atria. In diabetic rats co-administration of secretin + L-NAME increased the permeability of the atria and left ventricle, but L-NAME administered alone decreased them. Secretin modified the effect of L-NAME on coronary permeability in intact and diabetic rats. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:40:13