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Titolo:
Effects of centrally administered orexin-1 and orexinA: a role for orexin-1 receptors in orexin-B-induced hyperactivity
Autore:
Jones, DNC; Gartlon, J; Parker, F; Taylor, SG; Routledge, C; Hemmati, P; Munton, RP; Ashmeade, TE; Hatcher, JP; Johns, A; Porter, RA; Hagan, JJ; Hunter, AJ; Upton, N;
Indirizzi:
SmithKline Beecham Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England SmithKline Beecham Pharmaceut, Europe, Dept Discovery Chem, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 153, anno: 2001,
pagine: 210 - 218
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; SECRETION; PEPTIDES; NEUROENDOCRINE; STIMULATION; BEHAVIOR; SYSTEMS; HORMONE; NEURONS;
Keywords:
orexin-B; orexin-A; OX1 receptor; motor activity; grooming; prolactin; thyroid stimulating hormone (TSH) corticosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, DNC SmithKline Beecham Pharmaceut, Neurosci Res, New Frontiers Sci Pk,3rd Ave,Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut New Frontiers Sci Pk,3rd Ave Harlow Essex England CM19 5AW
Citazione:
D.N.C. Jones et al., "Effects of centrally administered orexin-1 and orexinA: a role for orexin-1 receptors in orexin-B-induced hyperactivity", PSYCHOPHAR, 153(2), 2001, pp. 210-218

Abstract

Rationale: Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and a role in the regulation of sleep-wake function. The in vivo role of orexin-B is not as clear. Objectives: To investigate the behavioural, endocrine and neurochemical effects of orexin-B in in-vivo tests. In a number of experiments, these effects were compared with those of orexin-A. Methods: Experiments were carried out in male, Sprague-Dawley rats with a guide cannula directed towards the lateral ventricle. The effects of orexin-B (ICV) upon grooming behaviour were compared with those of orexin-A. The effects of orexin-B upon the motor activity response to both novel and familiar environments were assessed in an automated activity monitor. Orexin-B was tested upon startle reactivity and body temperature. Further, plasma hormones and [DOPAC+ HVA]/[DA] and [5-HIAA]/[5-HT] ratios in six brain areas were measured 40min post-orexin-B or orexin-A. Results: The dearest behavioural response to orexin-B was increased motor activity in both novel and familiar environments. Orexin-B-induced hyperactivity was blocked by an OX1 receptor antagonist, Sb-334867-A, implicating OX, receptors in this behavioural response. In common with orexin-A, orexin-B reduced plasma prolactin and failed to influence startle reactivity. However, in contrast with orexin-A, orexin-B increased head grooming but failed to cause a robust whole body grooming response or increase plasma corticosterone levels. Further, orexin-B, but not orexin-A, increased plasma TSH and increased hypothalamic and striatal [5-HIAA]/[5-HT] ratios. Conclusions: The present study has demonstrated a number of behavioural, neuroendocrine and neurochemical effects of orexin-B that distinguish it from orexin-A. Further, we have demonstrated a role for OX1 receptors in the actions of orexin-B upon motor activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:21:21