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Titolo:
Cognitive performance and serotonergic function in users of ecstasy
Autore:
Verkes, RJ; Gijsman, HJ; Pieters, MSM; Schoemaker, RC; de Visser, S; Kuijpers, M; Pennings, EJM; de Bruin, D; Van de Wijngaart, G; Van Gerven, JMA; Cohen, AF;
Indirizzi:
Ctr Human Drug Res, NL-2333 CL Leiden, Netherlands Ctr Human Drug Res Leiden Netherlands NL-2333 CL CL Leiden, Netherlands Univ Med Ctr Nijmegen, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr Nijmegen Nijmegen Netherlands NL-6500 HB megen, Netherlands Leiden Univ, Med Ctr L1 39, Dept Toxicol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Addict Res Ctr, NL-3511 ZC Utrecht, Netherlands Addict Res Ctr Utrecht Netherlands NL-3511 ZC 11 ZC Utrecht, Netherlands
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 153, anno: 2001,
pagine: 196 - 202
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARD SORTING TEST; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; (+/-)3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; RECREATIONAL USE; MEMORY DEFICITS; HUMANS; MOOD; RESPONSES; DAMAGE;
Keywords:
MDMA; ecstasy; serotonin; memory; cognition; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Verkes, RJ Ctr Human Drug Res, Zernikedreef 10, NL-2333 CL Leiden, Netherlands Ctr Human Drug Res Zernikedreef 10 Leiden Netherlands NL-2333 CL
Citazione:
R.J. Verkes et al., "Cognitive performance and serotonergic function in users of ecstasy", PSYCHOPHAR, 153(2), 2001, pp. 196-202

Abstract

Rationale: (+/-) 3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") hasbeen shown to cause long term damage to serotonergic cerebral neurons in animals. The neurotoxic effects in humans are less clear and little is knownabout the functional consequences, although some studies suggest memory impairment. Given the widespread use of MDMA, our lack of knowledge raises concerns. Objective: We investigated, in humans, the relation between past use of ecstasy and cognitive performance as well as serotonergic function. Methods: Two groups of 21 males with moderate and heavy recreational use of MDMA, respectively, and a control group of 20 males without use of MDMA werecompared. All were from the same subculture. Reaction time, direct recall,and recognition were assessed. Serotonergic function was measured by the neuro-endocrine response to a placebo-controlled, crossover challenge with dexfenfluramine. Results: Ecstasy users showed a broad pattern of statistically significant, but clinically small, impairment of memory and prolonged reaction times. Heavy users were affected stronger than moderate users. Release of cortisol but not of prolactin after dexfenfluramine administration was significantly reduced in both groups of ecstasy users compared with the controls, Analyses of covariance showed that likely confounding variables including recent exposure to ecstasy, psychosocial profiles and use of otherdrugs did not explain the differences found between the groups. Conclusions: These results provide further evidence that use of ecstasy may be associated with impairment of memory and of serotonergic function. These findingsare compatible with neurotoxicity of ecstasy as shown in animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:26:11