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Titolo:
Pain and negative affect: evidence the inverse benzodiazepine agonist DMCMinhibits pain and learning in rats
Autore:
Sieve, AN; King, TE; Ferguson, AR; Grau, JW; Meagher, MW;
Indirizzi:
Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 sychol, College Stn, TX 77843 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 153, anno: 2001,
pagine: 180 - 190
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED OPIATE ANALGESIA; ACOUSTIC STARTLE REFLEX; PERIAQUEDUCTAL GRAY; STRIA TERMINALIS; SHOCK SEVERITY; FORMALIN TEST; BED NUCLEUS; BRAIN-STEM; ANXIETY; FEAR;
Keywords:
pain; Pavlovian conditioning; DMCM; anxiety; fear; panic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Sieve, AN Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 llege Stn, TX 77843 USA
Citazione:
A.N. Sieve et al., "Pain and negative affect: evidence the inverse benzodiazepine agonist DMCMinhibits pain and learning in rats", PSYCHOPHAR, 153(2), 2001, pp. 180-190

Abstract

Rationale: The anxiogenic DMCM, an inverse benzodiazepine agonist, was used to explore the relationship between negative affective states and pain. Past work suggests that the outcome obtained may depend on both the intensity of the affective state and the way in which pain is inferred. Objectives:The present study was designed to test the impact of relatively low doses of DMCM on multiple measures of pain reactivity and learning. Methods: In experiment 1, systemic injections of 0.00, 0.015, 0.06, and 0.25 mg/kg DMCM were administered before vocalization and tail movements were assessed in response to a gradually incremented shock and radiant heat stimulus. Experiment 2 tested the effects: of DMCM on Pavlovian conditioning. DMCM-treated subjects experienced a context paired with an aversive unconditioned stimulus (US) and conditioned freezing was assessed the next day. Results: Experiment 1 showed that DMCM inhibits both a spinal nociceptive reflex (tail-flick to heat) and a supraspinal measure of pain (vocalization to shock). Because these inhibitory effects could reflect a disruption in motor function, experiment 2 employed a remote test based on Pavlovian conditioning. A moderate dose of DMCM undermined learning, implying that the drug decreased the affective impact of the aversive US. Conclusions: DMCM induces hypoalgesia on a wide range of assays. Furthermore, pharmacologically inducing a negative affective state blocks Pavlovian fear conditioning. It is suggested thatDMCM induces a state of panic and that this state inhibits pain.

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Documento generato il 20/01/20 alle ore 16:03:45