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Titolo:
Involvement of D-2 dopamine receptors in the opposing effects of two CCK-Bagonists in a spatial recognition memory task: role of the anterior nucleus accumbens
Autore:
Lena, I; Dhotel, H; Garbay, C; Dauge, V;
Indirizzi:
UFR Sci Pharmaceut & Biol, Dept Pharmacochim Mol & Struct, CNRS, UMR 8600,INSERM,U266, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol Paris France 06 U266, F-75270 Paris 06, France
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 153, anno: 2001,
pagine: 170 - 179
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; FREELY MOVING RATS; ELEVATED PLUS-MAZE; EXTRACELLULAR DOPAMINE; BASOLATERAL AMYGDALA; ALTERNATION BEHAVIOR; AFFINITY STATES; CHOLECYSTOKININ; INJECTION; ANTAGONISTS;
Keywords:
CCK-B receptors heterogeneity; dopamine release; D-2 receptor; anterior nucleus accumbens; spatial recognition memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Dauge, V UFR Sci Pharmaceut & Biol, Dept Pharmacochim Mol & Struct, CNRS, UMR 8600,INSERM,U266, 4 Ave Observ, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol 4 Ave Observ Paris France 06 6, France
Citazione:
I. Lena et al., "Involvement of D-2 dopamine receptors in the opposing effects of two CCK-Bagonists in a spatial recognition memory task: role of the anterior nucleus accumbens", PSYCHOPHAR, 153(2), 2001, pp. 170-179

Abstract

Rationale: A previous study in the rat has shown that systemic injection of two CCK-B agonists, BC264 and BC197, induced opposing effects on the retrieval phase of a spatial recognition memory task. Objective: The present study was designed to investigate the mechanisms underlying these effects at the level of the dopaminergic system. Methods: Rats were injected IPly withBC264 (0.3 mug/kg) or BC197 (30 mug/kg) and with D-1 or D-2 agonists and antagonists. The cognitive performances of rat were analysed on the retrieval phase of a spatial recognition memory task. The extracellular levels of dopamine were quantified in the anterior nucleus accumbens after injection of BC197 (3, 30 and 300 mug/kg IP), using the microdialysis technique on freely moving rats. Local injection of the D-2 antagonist, sulpiride (2.5 ng/mul) was performed in the anterior nucleus accumbens and the cognitive performances analysed following systemic injection of BC264 (0.3 mug/kg). Results: The improvement and the impairment of performance induced respectively by BC264 and BC197 were suppressed by peripheral administration of sulpiride, showing that these opposing effects were both mediated by the stimulationof D-2-like receptors. However, different dopaminergic pathways seem to beinvolved in the effects of the two CCK-B agonists. Indeed, systemic administration of BC197 did not induce the increase of extracellular dopamine levels observed with BC264. Furthermore, local injection of sulpiride, in the anterior nucleus accumbens, completely suppressed the cognitive enhancing effect of BC264. Conclusion: These findings suggest that the D-2-mediated deficit in the performance induced by BC197 involves brain structures other than the anterior nucleus accumbens. They also demonstrate a critical role of dopaminergic transmission within the anterior nucleus accumbens in the improving effect induced by BC264 in a spatial memory task.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:52:18