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Titolo:
Long term modulation of the HPA axis by the hippocampus - Behavioral, biochemical and immunological endpoints in rats exposed to chronic mild stress
Autore:
Bratt, AM; Kelley, SP; Knowles, JP; Barrett, J; Davis, K; Davis, M; Mittleman, G;
Indirizzi:
Univ Memphis, Dept Psychol, Memphis, TN 38152 USA Univ Memphis Memphis TNUSA 38152 is, Dept Psychol, Memphis, TN 38152 USA Cat & Cow Vet Clin, Olive Branch, MS 38654 USA Cat & Cow Vet Clin Olive Branch MS USA 38654 , Olive Branch, MS 38654 USA Univ Memphis, Dept Biol, Memphis, TN 38152 USA Univ Memphis Memphis TN USA 38152 mphis, Dept Biol, Memphis, TN 38152 USA
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 2, volume: 26, anno: 2001,
pagine: 121 - 145
SICI:
0306-4530(200102)26:2<121:LTMOTH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENOCORTICAL AXIS; INDUCED CORTICOSTERONE SECRETION; RECEPTOR MESSENGER-RNAS; FOOD RESTRICTION; INDUCED SENSITIZATION; LOCOMOTOR-ACTIVITY; VENTRAL SUBICULUM; NUCLEUS-ACCUMBENS; KAINIC ACID; PARAVENTRICULAR NUCLEUS;
Keywords:
hippocampus; fimbria-fornix; subiculum; amphetamine; metryapone; corticosterone; locomotion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Bratt, AM Univ Calif San Francisco, Ernest Gallo Res Ctr, 5858 Horton St,Suite 200, Emeryville, CA 94608 USA Univ Calif San Francisco 5858 Horton St,Suite 200 Emeryville CA USA 94608
Citazione:
A.M. Bratt et al., "Long term modulation of the HPA axis by the hippocampus - Behavioral, biochemical and immunological endpoints in rats exposed to chronic mild stress", PSYCHONEURO, 26(2), 2001, pp. 121-145

Abstract

Mature rats were given lesions of the hippocampus (HIPPO), subiculum (SUBIC) or fimbria-fornix (FIFO) and then received the mild chronic stressors offood deprivation and isolation housing for ten months prior to testing. Group differences in circadian activity were investigated along with locomotion elicited by amphetamine (AMP 1.0-2.0 mg/kg i.p.) alone, and following the corticosterone (CORT) synthesis inhibitor, metyrapone (MET 10.0-25.0 mg/kg i.p.), Basal levels of plasma CORT, (ng/ml), plasma glucose (GLUC, mmol/l), thymic and splenic wet weights were subsequently determined along with complete blood counts (CBC). In comparison to age matched, unoperated controls, selective SUBIC lesions altered the circadian periodicity of locomotion, while rats with FIFO lesions were spontaneously hyperactive. Both HIPPO and FIFO animals showed significantly higher levels of amphetamine-induced locomotion. In all groups metyrapone significantly enhanced locomotion elicited by amphetamine, probably due to a pharmacokinetic interaction between these drugs. In comparison to controls, animals in the HIPPO group showed significant reductions in plasma glucose levels, decreased thymic wet weightsand reductions in lymphocyte numbers, indicating lesion-related immune-suppression. These findings highlight a functional difference among the effects of these specific hippocampal lesions on neural regulation of the HPA axis, under conditions of chronic mild stress, suggesting that the modulatory influence of the hippocampus on the stress axis is dependent on the neuroanatomical location and total extent of cell loss within this structure. Theyfurther suggest that the heightened response to amphetamine occurs independently of any lesion-induced changes in modulation of the HPA axis. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:41:34