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Titolo:
The HNK-1 carbohydrate epitope in the eye: Basic science and functional implications
Autore:
Uusitalo, M; Kivela, T;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Ophthalmol, Ophthal Pathol Lab, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ab, FIN-00029 Helsinki, Finland
Titolo Testata:
PROGRESS IN RETINAL AND EYE RESEARCH
fascicolo: 1, volume: 20, anno: 2001,
pagine: 1 - 28
SICI:
1350-9462(200101)20:1<1:THCEIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN-ASSOCIATED GLYCOPROTEIN; CELL-ADHESION MOLECULES; MONOCLONAL-ANTIBODY HNK-1; CHONDROITIN SULFATE PROTEOGLYCANS; NATURAL-KILLER CELLS; NEURAL CREST CELLS; HUMAN CILIARY BODY; CONNECTIVE-TISSUE LAYER; IMMUNOELECTRON MICROSCOPIC LOCALIZATION; PERIPHERAL NERVOUS-SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
192
Recensione:
Indirizzi per estratti:
Indirizzo: Uusitalo, M Univ Helsinki, Cent Hosp, Dept Ophthalmol, Ophthal Pathol Lab,POB 220,Haartmaninkatu 4C, FIN-00029 Helsinki, Finland Univ Helsinki POB 220,Haartmaninkatu 4C Helsinki Finland FIN-00029
Citazione:
M. Uusitalo e T. Kivela, "The HNK-1 carbohydrate epitope in the eye: Basic science and functional implications", PROG RET EY, 20(1), 2001, pp. 1-28

Abstract

The HNK-1 carbohydrate. epitope is part of many cell membrane and extracellular matrix molecules. It has been implicated in cell to cell and cell to extracellular matrix adhesion, and antibodies to the HNK-1 epitope are emerging as a versatile tool in eye research. They. have been used to identify a novel cell type in the human eye, the subepithelial matrix cells that reside in the inner connective tissue layer (ICTL) of the ciliary body. Although these cells resemble fibroblasts in ultrastructure. they. form a distinct cell population that differs in its antigenic profile from fibroblasts ofother tissues. These cells are associated with the elastic fiber system ofthe ICTL. Other structures in the human eye that harbor the HNK-1 epitope in a nonrandom pattern are the ciliary and iris epithelia. the zonular lamella. the lens capsule, the retina, glial cells of the optic and ciliary nerves, and scleral fibroblasts. The HNK-1 epitope in the eye appears early during embryonic development and is phylogenetically conserved, but many interspecies differences exist in its distribution. The role of the HNK-1 epitope may be to structurally stabilize the ciliary body and the retina, and toparticipate in zonular attachments. The HNK-1 epitope: has been linked with many common eye diseases. The subepithelial matrix cells seem to be susceptible to undergo irreversible damage as a result of glaucoma, thermal injury, and tissue compression. This epitope has proved to be useful in identifying intraocular deposits of exfoliation syndrome. It can explain the adhesiveness of exfoliation material. Intraocular exfoliation material differs in HNK-1 immunoreactivity from the extraocular fibrillopathy of exfoliation syndrome and its presence in fellow eyes also argues against the concept ofunilateral exfoliation syndrome. The HNK-1 epitope is found in the extracellular matrix of secondary cataract and anterior subcapsular cataract, and it may contribute to their pathogenesis. Finally, the HNK-1 epitope: can beused to trace neuroepithelial derivatives of the optic vesicle in developmental anomalies and in tumors of the eye. Eventual identification of molecules that bear the HNK-1 epitope in the eye will likely shed light on many aspects of ocular physiology and pathobiology (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:17:27