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Titolo:
Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups
Autore:
Zhang, YY; Hufnagel, C; Eiden, S; Guo, KY; Diaz, PA; Leibel, RL; Schmidt, I;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Div Mol Genet, Dept Pediat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Pediat, New York, NY 10032 USA Max Planck Inst, Physiol & Klin Forsch, WG Kerckhoff Inst, D-61231 Bad Nauheim, Germany Max Planck Inst Bad Nauheim Germany D-61231 D-61231 Bad Nauheim, Germany
Titolo Testata:
PHYSIOLOGICAL GENOMICS
fascicolo: 3, volume: 4, anno: 2001,
pagine: 189 - 199
SICI:
1094-8341(20010119)4:3<189:MFLROL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; OB GENE-EXPRESSION; ADIPOSE-TISSUE; OBESE GENE; UNCOUPLING PROTEIN; JUVENILE RATS; COLD DEFENSE; ZUCKER RATS; MICE; RECEPTOR;
Keywords:
energy metabolism; obesity; sympathetic nervous system; leptin receptor; adipose tissue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, YY Columbia Univ, Coll Phys & Surg, Div Mol Genet, Dept Pediat, Russ Barrie Pavil,1150 St Nicholas Ave, New York, NY 10032 USA Columbia Univ Russ Barrie Pavil,1150 St Nicholas Ave New York NY USA 10032
Citazione:
Y.Y. Zhang et al., "Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups", PHYSIOL GEN, 4(3), 2001, pp. 189-199

Abstract

To investigate the underlying mechanisms for leptin receptor (LEPR)-mediated regulation of leptin gene (Lep) expression in brown (BAT) and white (WAT) adipose tissue and resultant effects on plasma leptin concentrations (plasma-LEP), we examined effects of sympathetic nervous system (SNS) activity,caloric balance, and body fat content on leptin mRNA levels in BAT and WATin 10-day-old rat pups segregating for Lepr(fa). In mother-reared pups, Lep mRNA levels were fa/fa > +/fa = +/+ in BAT and was fa/fa > +/fa > +/+ in WAT. The genotype effects on Lep expression in BAT and plasma-LEP were virtually eliminated when the differences in SNS activity between fa/fa and +/fa pups were equalized by artificial rearing of pups under thermoneutral conditions with or without oral norepinephrine (NE) administration. NE administration alone had little effect on the Lepr(fa)-dependent stratification ofLep expression in WAT. BAT-Lep mRNA was the main determinant of plasma-LEP. Metabolic rate, a surrogate indicator of SNS activity, explained 87% of the variation in BAT-Lep mRNA (R-2 = 0.93), whereas caloric balance (40%) and body fat mass (6%) accounted for most of the variation in WAT-Lep mRNA (R-2 = 0.53). We conclude that feedback regulation of Lep expression in BAT is primarily via central nervous system-mediated effects of leptin on SNS activity, whereas the control of leptin expression in WAT is more likely via mechanisms not directly dependent on SNS activity.

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Documento generato il 25/01/20 alle ore 15:54:46