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Titolo:
Study of the distribution pattern of Schistosoma haematobium egg antigens recognised by six different monoclonal antibodies in the parasite and the host
Autore:
Royers, R; Jacobs, W; Bogers, JJ; Deelder, AM; Van Marck, E;
Indirizzi:
Univ Antwerp, Dept Pathol, Pathol Lab, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 Pathol Lab, B-2610 Wilrijk, Belgium Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands Leiden Univ Leiden Netherlands Ctr, Dept Parasitol, Leiden, Netherlands
Titolo Testata:
PARASITE-JOURNAL DE LA SOCIETE FRANCAISE DE PARASITOLOGIE
fascicolo: 4, volume: 7, anno: 2000,
pagine: 297 - 303
SICI:
1252-607X(200012)7:4<297:SOTDPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING CATHODIC ANTIGEN; ULTRASTRUCTURAL-LOCALIZATION; DIGESTIVE-TRACT; ANODIC ANTIGEN; MANSONI EGGS; INDUCTION; URINE; CARBOHYDRATE; DISEASE; REVEALS;
Keywords:
Schistosoma haematobium; egg antigen; immunolocalisation; parasite; host; hatching fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Van Marck, E Univ Antwerp, Dept Pathol, Pathol Lab, Univ Pl 1, B-2610 Wilrijk, Belgium Univ Antwerp Univ Pl 1 Wilrijk Belgium B-2610 lrijk, Belgium
Citazione:
R. Royers et al., "Study of the distribution pattern of Schistosoma haematobium egg antigens recognised by six different monoclonal antibodies in the parasite and the host", PARASITE, 7(4), 2000, pp. 297-303

Abstract

Recently a new panel of monoclonal antibodies was developed against soluble egg antigens in the hatching fluid of Schistosoma mansoni. These antibodies have been used to develop on improved ELISA for the detection of circulating soluble egg antigens in serum and urine that would have a higher sensitivity in the immunodiagnosis of S. mansoni infections. Although these antibodies showed no improvement in the immunodiagnosis of S. mansoni infections compared with egg antigen-based ELISAs already described (Nourel Din et al., 1994a), they may have a potential role in the identification of S. haematobium infections. This study has looked into the immunolocalisation of S.haematobium egg antigens in both the parasite and the host as recognised by four newly developed monoclonal antibodies (290-2D9-A, 290-2E6-A, 290-2H12-A and 290-4A8-A) and two already described antibodies (114-581-A and 114-4D12-A). The antibodies 114-5B1-A and 114-4D12-A appeared to have in S. haematobium eggs a similar staining pattern when compared to S. mansoni eggs. The antibodies prepared against the hatching fluid showed a characteristic signal, especially 290-2E6-A. These antibodies recognised a component originating from the lateral glands of the miracidium. In the host a similar immunohistochemical tissue localisation pattern (mainly phagocytising reticulo-endothelial cells) was seen as previously described for S. mansoni infected hamsters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:07:47