Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13)
Autore:
Niitsu, N; Hayashi, Y; Honma, Y;
Indirizzi:
Saitama Canc Ctr, Res Inst, Ina, Saitama 3620806, Japan Saitama Canc Ctr Ina Saitama Japan 3620806 t, Ina, Saitama 3620806, Japan Toho Univ, Sch Med, Dept Internal Med 1, Tokyo 153, Japan Toho Univ Tokyo Japan 153 Sch Med, Dept Internal Med 1, Tokyo 153, Japan Univ Tokyo, Fac Med, Dept Pediat, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 Tokyo, Fac Med, Dept Pediat, Tokyo 113, Japan
Titolo Testata:
ONCOGENE
fascicolo: 3, volume: 20, anno: 2001,
pagine: 375 - 384
SICI:
0950-9232(20010118)20:3<375:DOMFGE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOID-X-RECEPTOR; ACUTE MYELOID-LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; NUCLEAR-PROTEIN CBP; HISTONE ACETYLTRANSFERASE; BUTYRIC-ACID; SODIUM-BUTYRATE; TRANSCRIPTIONAL ACTIVATION; MYELOMONOCYTIC LEUKEMIA;
Keywords:
differentiation; MLL-CBP; t(11;16)(q23;p13); RXR agonist, butyrate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Honma, Y Saitama Canc Ctr, Res Inst, Ina, Saitama 3620806, Japan Saitama Canc Ctr Ina Saitama Japan 3620806 aitama 3620806, Japan
Citazione:
N. Niitsu et al., "Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13)", ONCOGENE, 20(3), 2001, pp. 375-384

Abstract

The translocation t(11;16)(q23;p13) has only been documented in patients with acute leukemia or myelodysplasia secondary to therapy with drugs targeting DNA topoisomerase II. We have established a myeloid cell line (SN-1) with the MLL-CBP fusion gene from an acute leukemia patient with t(11;16)(q23;p13), Although SN-1 cells were not induced to differentiate by all-tr mw retinoic acid (ATRA) and 1 alpha ,25-dihydroxyvitamin D-3 (VD3), retinoid Iireceptor (RXR) agonists, such as 9-cis retinoic acid and Ro48-2250, effectively induced differentiation of the cells. Downregulation of the expression of the MLL-CBP fusion gene occurred during the differentiation of SN-1 cells, When SN-1 cells were treated with MLL-CBP antisense oligonucleotide, the cells were induced to differentiate by ATRA or VD3, suggesting that the MLL-CBP fusion gene dominant-negatively suppresses ATRA- or VD3-induced differentiation. Moreover, suboptimal concentrations of sodium butyrate, a histone deacetylase inhibitor, had a cooperative effect with ATRA or VD3 in inducing the differentiation of SN-1 cells, The downregulation of the expression of MLL-CBP mRNA was accompanied by the induction of differentiation. These findings suggest that RXR agonists or a clinically applicable combination of ATRA and butyrate derivatives might be useful for differentiation therapy in leukemia patients with the MLL-CBP fusion gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:24:08