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Titolo:
Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment
Autore:
Qiao, H; Noda, Y; Kamei, H; Nagai, T; Furukawa, H; Miura, H; Kayukawa, Y; Ohta, T; Nabeshima, T;
Indirizzi:
Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Nagoya, Aichi, JapanNagoya Univ Nagoya Aichi Japan europsychopharmacol, Nagoya, Aichi, Japan Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan Med, Dept Psychiat, Nagoya, Aichi, Japan Nagoya Univ, Grad Sch Med, Dept Hosp Pharm, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan ed, Dept Hosp Pharm, Nagoya, Aichi, Japan Meijo Univ, Fac Pharmaceut Sci, Dept Med Chem, Nagoya, Aichi, Japan Meijo Univ Nagoya Aichi Japan t Sci, Dept Med Chem, Nagoya, Aichi, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 12, anno: 2001,
pagine: 11 - 15
SICI:
0959-4965(20010122)12:1<11:CBNHRS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; ANIMAL-MODELS; D-AMPHETAMINE; SCHIZOPHRENIA; ANTAGONISTS; RECEPTORS; RATS; PSYCHOSIS;
Keywords:
clozapine; haloperidol; negative symptom; phencyclidine (PCP); social behavior (SB);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nabeshima, T Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Nagoya,Aichi, Japan Nagoya Univ Nagoya Aichi Japan rmacol, Nagoya, Aichi, Japan
Citazione:
H. Qiao et al., "Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment", NEUROREPORT, 12(1), 2001, pp. 11-15

Abstract

Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SE deficit was observed on repeated treatment with methamphetamine for 14 days. The SE deficit produced by treatment with PCP (10 mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, aloneat the same treatment dose increased SE in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to testbeneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SE deficit. NeuroReport 12:11-15 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:43:54