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Titolo:
Galanin/alpha 2-adrenoceptor interactions in telencephalic and diencephalic regions of the rat
Autore:
Diaz-Cabiale, Z; Narvaez, JA; Garcia-Coronel, M; Fuxe, K;
Indirizzi:
Karolinska Inst, Dept Neurosci, BZ Lab, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Lab, S-17177 Stockholm, Sweden Fac Med, Dept Fisiol, Malaga 29080, Spain Fac Med Malaga Spain 29080Fac Med, Dept Fisiol, Malaga 29080, Spain
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 12, anno: 2001,
pagine: 151 - 155
SICI:
0959-4965(20010122)12:1<151:G2IITA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; NEUROPEPTIDE-Y; GALANIN; MECHANISMS; RECEPTOR; RELEASE; PEPTIDE; HYPOTHALAMUS; NUCLEUS; NEURONS;
Keywords:
alpha2-adrenoceptor; autoradiography; brain; galanin; galanin receptor; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Diaz-Cabiale, Z Karolinska Inst, Dept Neurosci, BZ Lab, S-17177 Stockholm,Sweden Karolinska Inst Stockholm Sweden S-17177 ockholm, Sweden
Citazione:
Z. Diaz-Cabiale et al., "Galanin/alpha 2-adrenoceptor interactions in telencephalic and diencephalic regions of the rat", NEUROREPORT, 12(1), 2001, pp. 151-155

Abstract

The aim of this study was to evaluate whether galanin could affect centralalpha2-adrenoceptors in telencephalic and diencephalic regions in the rat using quantitative receptor autoradiography with the alpha2 agonist radioligand [H-3] p-aminoclonidine. Galanin I nM significantly and substantially increased the K-d value of the [H-3] p-aminoclonidine binding sites in the medial hypothalamus and amygdala by 86% (p<0.01) and 73% (p<0.05) respectively. The B-max value was only significantly increased with 3 nM galanin in the amygdala and the medial hypothalamus (both p<0.05). The antagonist M35 counteracted the increase of the K-d values of the <alpha>2-adrenoceptor agonist binding sites produced by galanin 1 nM in the amygdala and the medial hypothalamus (both P < 0.001). These findings suggest the existence of an antagonistic galanin/<alpha>2 adrenoceptor interaction in the medial hypothalamus and amygdala that may be of relevance for alpha2-adrenoceptor-regulated neuroendocrine functions and food intake. NeuroReport 12:151-155 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:18:10