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Titolo:
Induction of hippocampal glial cells expressing basic fibroblast growth factor RNA by corticosterone
Autore:
Hansson, AC; Sommer, W; Andbjer, B; Bader, M; Ganten, D; Fuxe, K;
Indirizzi:
Karolinska Inst, Dept Neurosci, Div Mol & Cellular Neurochem, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 chem, S-17177 Stockholm, Sweden Karolinska Inst, NEUROTEC, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 OTEC, S-17177 Stockholm, Sweden Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany D-13125 D-13125 Berlin, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 12, anno: 2001,
pagine: 141 - 145
SICI:
0959-4965(20010122)12:1<141:IOHGCE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RECEPTOR; RAT HIPPOCAMPUS; GENE-EXPRESSION; MESSENGER-RNAS; C-JUN; ASTROCYTES; NUCLEAR; PROTEIN;
Keywords:
ADX; bFGF; corticosterone; gene regulation; in situ hybridization; rat brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hansson, AC Karolinska Inst, Dept Neurosci, Div Mol & Cellular Neurochem, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 7 Stockholm, Sweden
Citazione:
A.C. Hansson et al., "Induction of hippocampal glial cells expressing basic fibroblast growth factor RNA by corticosterone", NEUROREPORT, 12(1), 2001, pp. 141-145

Abstract

A transcriptional regulation of bFGF expression via both gluco- and mineralocorticoid receptors is known to exist. In the present study the glial nuclear fraction of bFGF transcripts was studied in sham-operated (SHAM), adrenalectomized (ADX), and corticosterone-treated ADX rats in subregions of the dorsal hippocampal formation. A substantial increase was observed in the population of bFGF RNA-expressing glial cells after acute corticosterone treatment (10 mg/kg, s.c.) in subregions of the CA1 area and the dentate gyrus but no changes were observed after adrenalectomy. The levels of glial nuclear bFGF transcripts were similar in all the experimental groups. These data suggest that in a subpopulation of hippocampal glial cells corticosterone regulates bFGF gene expression transcriptionally in an on/off manner. NeuroReport 12:141-145 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 27/01/20 alle ore 14:54:53