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Titolo:
Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis
Autore:
Lukiw, WJ; Gordon, WC; Rogaev, EI; Thompson, H; Bazan, NG;
Indirizzi:
Louisiana State Univ, Sch Med, Ctr Neurosci, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana State Univ, Sch Med, Dept Ophthalmol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Russian Acad Med Sci, Lab Mol Brain Genet, Moscow 113152, Russia Russian Acad Med Sci Moscow Russia 113152 n Genet, Moscow 113152, Russia
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 12, anno: 2001,
pagine: 53 - 57
SICI:
0959-4965(20010122)12:1<53:P(EUIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; GENOMIC STRUCTURE; GENE; DNA; HYPOXIA;
Keywords:
Alzheimer's disease (AD); beta-amyloid precursor protein (beta APP); angiogenesis; HIF-1; hyperoxia; neovascularization (NV); presenilin; PS2; reactive oxygen species (ROS); retinopathy; transcription;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Bazan, NG Louisiana State Univ, Sch Med, Ctr Neurosci, 2020 Gravier St,Suite D, New Orleans, LA 70112 USA Louisiana State Univ 2020 Gravier St,Suite D New Orleans LA USA 70112
Citazione:
W.J. Lukiw et al., "Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis", NEUROREPORT, 12(1), 2001, pp. 53-57

Abstract

Presenilin-2 (PS2; AD4), a regulator of intercellular signaling during CNSdevelopment and cell fate determination, appears to be involved in pathogenic processing of beta -amyloid precursor protein (beta APP) into potentially neurotoxic beta -amyloid (A beta) peptides. The PS2 gene promoter contains multiple DNA binding sites for the relatively rare hypoxia-inducible transcription factor HIF-I, suggesting that PS2 expression may be a sensitive indicator of decreased oxygen availability. We have used a cycled hypoxia/hyperoxia (10-50% O-2) protocol followed by normoxia (20% O-2) as a retinal model of retinopathy of prematurity to induce neovascularization (NV) in rat pups. Retinal cell nuclear extracts from pups undergoing hypoxia exhibited a dramatic increase in HIF-I-DNA binding, followed by a delayed (2-7 day)elevation of PS2 RNA message and protein. PS2 gene activation during hypoxia may direct cellular fate towards pathoangiogenesis and intercellular PS2-mediated signaling dysfunction. NeuroReport 12:53-57 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 22/01/20 alle ore 07:21:31