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Titolo:
Origins of spontaneous and noxious stimuli-evoked miniature EPSCs in substantia gelatinosa
Autore:
Yang, K; Li, YQ;
Indirizzi:
Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 1, volume: 12, anno: 2001,
pagine: 39 - 42
SICI:
0959-4965(20010122)12:1<39:OOSANS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; PRIMARY SENSORY NEURONS; SYNAPTIC TRANSMISSION; CAPSAICIN RECEPTOR; SODIUM-CHANNELS; SLICES; MECHANISMS; GLUTAMATE; SYNAPSES; CURRENTS;
Keywords:
excitatory postsynaptic currents; noxious stimulation; rat; spinal cord slice; substantia gelatinosa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Li, YQ Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China FourthMil Med Univ Xian Peoples R China 710032 , Peoples R China
Citazione:
K. Yang e Y.Q. Li, "Origins of spontaneous and noxious stimuli-evoked miniature EPSCs in substantia gelatinosa", NEUROREPORT, 12(1), 2001, pp. 39-42

Abstract

The origins of spontaneous and noxious stimuli-evoked glutamatergic miniature excitatory postsynaptic currents (mEPSCs) in substantia gelatinosa (SG)neurons were investigated by using whole-cell voltage-clamp technique on adult rat spinal cord slice. The properties of mEPSCs of SG neurons from rats either neonatally capsaicin-treated or sciatic nerve ligated showed no difference from those of intact SG neurons, indicating independence of spontaneous mEPSCs on primary afferent fibers. In the presence of tetrodotoxin (TTX), capsaicin, which noxiously stimulated fine primary afferent fibers, caused increase of the mEPSCs frequency, but did not affect the amplitude profiles or mean amplitudes. TTX affected neither the spontaneous mEPSCs nor capsaicin-induced mEPSCs frequency increase. The results suggest that spontaneous mEPSCs in SG are mediated by presynaptic spontaneous glutamate release predominantly originating from interneuron terminals rather than from primary afferent terminals; under noxious stimulation, however, mEPSCs frequency increase is mediated by primary afferent excitation. NeuroReport 12:39-42 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:24:59