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Titolo:
Analysis of calcium imaging signals from the honeybee brain by nonlinear models
Autore:
Stetter, M; Greve, H; Galizia, CG; Obermayer, K;
Indirizzi:
Tech Univ Berlin, Dept Comp Sci, D-10587 Berlin, Germany Tech Univ BerlinBerlin Germany D-10587 omp Sci, D-10587 Berlin, Germany Free Univ Berlin, Dept Neurobiol, D-14159 Berlin, Germany Free Univ Berlin Berlin Germany D-14159 urobiol, D-14159 Berlin, Germany Siemens AG, Corp Technol Dept, D-81730 Munich, Germany Siemens AG MunichGermany D-81730 Technol Dept, D-81730 Munich, Germany
Titolo Testata:
NEUROIMAGE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 119 - 128
SICI:
1053-8119(200101)13:1<119:AOCISF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONKEY STRIATE CORTEX; CA2+; SELECTIVITY; INDICATORS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Stetter, M Tech Univ Berlin, Dept Comp Sci, FR2-1,Franklinstr 28-29, D-10587 Berlin, Germany Tech Univ Berlin FR2-1,Franklinstr 28-29 Berlin GermanyD-10587
Citazione:
M. Stetter et al., "Analysis of calcium imaging signals from the honeybee brain by nonlinear models", NEUROIMAGE, 13(1), 2001, pp. 119-128

Abstract

Recent Ca2+-imaging studies on the antennal lobe of the honeybee (Apis mellifera) have shown that olfactory stimuli evoke complex spatiotemporal changes of the intracellular Ca2+ concentration, in which stimulus-dependent subsets of glomeruli are highlighted. In this work we use nonlinear models for the quantitative identification of the spatial and temporal properties ofthe Ca2+-dependent fluorescence signal. This technique describes time series of the Ca2+ signal as a superposition of biophysically motivated model functions for photobleaching and Ca2+ dynamics and provides optimal estimates of their amplitudes (signal strengths) and time constants together with error measures. Using this method, we can reliably identify two different stimulus-dependent signal components. Their delays and rise times, delta (c1)= (0.4 +/- 0.3) s, tau (c1) = (3.8 +/- 1.2) s for the fast component and delta (c2) = (2.4 +/- 0.6) s, tau (c2) = (10.3 +/- 3.2) s for the slow component, are constant over space and across different odors and animals. In chronological experiments, the amplitude of the fast (slow) component often decreases (increases) with time. The pattern of the Ca2+ dynamics in space and time can be reliably described as a superposition of only two spatiotemporally separable patterns based on the fast and slow components. However, the distributions of both components over space turn out to differ from eachother, and more work has to be done in order to specify their relationshipwith neuronal activity. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:37:10