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Titolo:
Adequacy of dialysis reduces the doses of recombinant erythropoietin independently from the use of biocompatible membranes in haemodialysis patients
Autore:
Movilli, E; Cancarini, GC; Zani, R; Camerini, C; Sandrini, M; Maiorca, R;
Indirizzi:
Spedali Civili, Div Nephrol, I-25123 Brescia, Italy Spedali Civili Brescia Italy I-25123 Div Nephrol, I-25123 Brescia, Italy Spedali Civili, Chair Nephrol, I-25123 Brescia, Italy Spedali Civili Brescia Italy I-25123 air Nephrol, I-25123 Brescia, Italy Univ Brescia, I-25121 Brescia, Italy Univ Brescia Brescia Italy I-25121Univ Brescia, I-25121 Brescia, Italy
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 1, volume: 16, anno: 2001,
pagine: 111 - 114
SICI:
0931-0509(200101)16:1<111:AODRTD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; CLINICAL-TRIAL; HEMODIALYSIS; MORTALITY; ANEMIA;
Keywords:
adequacy; anaemia; biocompatibility; Epo dose; haemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Movilli, E Spedali Civili, Div Nephrol, P Osped Civile 1, I-25123 Brescia,Italy Spedali Civili P Osped Civile 1 Brescia Italy I-25123 a, Italy
Citazione:
E. Movilli et al., "Adequacy of dialysis reduces the doses of recombinant erythropoietin independently from the use of biocompatible membranes in haemodialysis patients", NEPH DIAL T, 16(1), 2001, pp. 111-114

Abstract

Background. The effect of the adequacy of dialysis on the response to recombinant human erythropoietin (rHuEpo) therapy is still incompletely understood because of many confounding factors such as iron deficiency, biocompatibility of dialysis membranes, and dialysis modality that can interfere. Methods. We investigated the relationship between Kt/V and the weekly doseof rHuEpo in 68 stable haemodialysis (HD) patients (age 65+/-15 years) treated with bicarbonate HD and unsubstituted cellulose membranes for 6-343 months (median 67 months). Inclusion criteria were HD for at least 6 months, subcutaneous rHuEpo for at least 4 months, transferrin saturation (TSAT) greater than or equal to 20%, serum ferritin greater than or equal to 100 ng/ml, and haematocrit (Hct) level targeted to 35% for at least 3 months. Exclusion criteria included HBsAg and HIV positivity, need for blood transfusions or evidence of blood loss in the 3 months before the study, and acute orchronic infections. Hct and haemoglobin (Hb) levels were evaluated weekly for 4 weeks; TSAT, serum ferritin, Kt/V, PCRn, serum albumin (sAlb), and weekly dose of rHuEpo were evaluated at the end of observation. No change in dialysis or therapy prescription was made during the study. Results. The results for the whole group of patients were: Hct 35+/-1.2%, Hb 12.1+/-0.6 g/dl, TSAT 29+/- 10%, serum ferritin 204+/-98 ng/ml, sAlb 4.1/-0.3 g/dl, Kt/V 1.33+/-0.19, PCRn 1.11+/-0.28 g/kg/day, weekly dose of rHuEpo 123+/-76 U/kg. Hct did not correlate with Kt/V, whereas rHuEpo dose and Kt/V were inversely correlated (r=-0.49; P<0.0001). Multiple regression analysis with rHuEpo as dependent variable confirmed Kt/V as the only significant variable (P<0.002). Division of the patients into two groups according to Kt/V (group A, Kt/V less than or equal to1.2; group B, Kt/V greater than or equal to1.4), showed no differences in Hct levels between the two groups, while weekly rHuEpo dose was significantly lower in group B than in group A (group B, 86+/-33 U/kg; group A, 183+/-95 U/kg, P<0.0001). Conclusions. In iron-replete HD patients treated with rHuEpo in the maintenance phase, Kt/V exerts a significant sparing effect on rHuEpo requirementindependent of the use of biocompatible synthetic membranes. By optimizingrHuEpo responsiveness, an adequate dialysis treatment can contribute to the reduction of the costs of rHuEpo therapy.

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Documento generato il 06/04/20 alle ore 02:11:11