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Titolo:
Genome sequence of enterohaemorrhagic Escherichia coli O157 : H7
Autore:
Perna, NT; Plunkett, G; Burland, V; Mau, B; Glasner, JD; Rose, DJ; Mayhew, GF; Evans, PS; Gregor, J; Kirkpatrick, HA; Posfai, G; Hackett, J; Klink, S; Boutin, A; Shao, Y; Miller, L; Grotbeck, EJ; Davis, NW; Limk, A; Dimalanta, ET; Potamousis, KD; Apodaca, J; Anantharaman, TS; Lin, JY; Yen, G; Schwartz, DC; Welch, RA; Blattner, FR;
Indirizzi:
Univ Wisconsin, Genome Ctr Wisconsin, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Ctr Wisconsin, Madison, WI 53706 USA Univ Wisconsin, Dept Anim Hlth & Biomed Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 h & Biomed Sci, Madison, WI 53706 USA Univ Wisconsin, Genet Lab, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Genet Lab, Madison, WI 53706 USA Univ Wisconsin, Dept Chem, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Dept Chem, Madison, WI 53706 USA Univ Wisconsin, Dept Biostat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Biostat, Madison, WI 53706 USA Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 biol & Immunol, Madison, WI 53706 USA Cereon Genom LLC, Cambridge, MA 02139 USA Cereon Genom LLC Cambridge MA USA 02139 enom LLC, Cambridge, MA 02139 USA Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary Biol Res Ctr Szeged Hungary H-6701 Inst Biochem, H-6701 Szeged, Hungary
Titolo Testata:
NATURE
fascicolo: 6819, volume: 409, anno: 2001,
pagine: 529 - 533
SICI:
0028-0836(20010125)409:6819<529:GSOEEC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHIGA-LIKE TOXIN; SUBINHIBITORY CONCENTRATIONS; HEMORRHAGIC COLITIS; ALIGNMENT; EVOLUTION; REGIONS; GENES; K-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Perna, NT Univ Wisconsin, Genome Ctr Wisconsin, Madison, WI 53706 USA UnivWisconsin Madison WI USA 53706 nsin, Madison, WI 53706 USA
Citazione:
N.T. Perna et al., "Genome sequence of enterohaemorrhagic Escherichia coli O157 : H7", NATURE, 409(6819), 2001, pp. 529-533

Abstract

The bacterium Escherichia coli O157:H7 is a worldwide threat to public health and has been implicated in many outbreaks of haemorrhagic colitis, someof which included fatalities caused by haemolytic uraemic syndrome(1,2). Close to 75,000 cases of O157:H7 infection are now estimated to occur annually in the United States(3). The severity of disease, the lack of effective treatment and the potential for large-scale outbreaks from contaminated food supplies have propelled intensive research on the pathogenesis and detection of E. coli O157:H7 (ref. 4). Here we have sequenced the genome of E. coli O157:H7 to identify candidate genes responsible for pathogenesis, to develop better methods of strain detection and to advance our understanding ofthe evolution of E. coli, through comparison with the genome of the non-pathogenic laboratory strain E. coli K-12 (ref. 5). We rnd that lateral gene transfer is far more extensive than previously anticipated. In fact, 1,387 new genes encoded in strain-specific clusters of diverse sizes were found in O157:H7. These include candidate virulence factors, alternative metaboliccapacities, several prophages and other new functions-all of which could be targets for surveillance.

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Documento generato il 21/09/20 alle ore 11:10:21