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Titolo:
Antimutagenic activity of fluphenazine in short-term tests
Autore:
Gasiorowski, K; Brokos, B; Szyba, K; Leszek, J;
Indirizzi:
Wroclaw Med Univ, Dept Basic Med Sci, PL-51601 Wroclaw, Poland Wroclaw MedUniv Wroclaw Poland PL-51601 d Sci, PL-51601 Wroclaw, Poland Wroclaw Med Univ, Psychiat Clin, PL-50229 Wroclaw, Poland Wroclaw Med Univ Wroclaw Poland PL-50229 Clin, PL-50229 Wroclaw, Poland
Titolo Testata:
MUTAGENESIS
fascicolo: 1, volume: 16, anno: 2001,
pagine: 31 - 38
SICI:
0267-8357(200101)16:1<31:AAOFIS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN KINASE-C; MONOCLONAL-ANTIBODIES; METABOLIC-ACTIVATION; PSYCHOTROPIC-DRUGS; MUTAGENICITY TEST; DNA-DAMAGE; CARCINOGENESIS; P53; BROMODEOXYURIDINE; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Gasiorowski, K Wroclaw Med Univ, Dept Basic Med Sci, 14 Kochanowskiego Str, PL-51601 Wroclaw, Poland Wroclaw Med Univ 14 Kochanowskiego Str Wroclaw Poland PL-51601
Citazione:
K. Gasiorowski et al., "Antimutagenic activity of fluphenazine in short-term tests", MUTAGENESIS, 16(1), 2001, pp. 31-38

Abstract

Fluphenazine, an antipsychotic drug that belongs to the phenothiazine family, reduced the genotoxicity of standard direct- and indirect-acting mutagens in the Ames test, both in the presence and in the absence of promutagen-activating So fraction. In short-term tests on human lymphocytes, the inhibitory effect of fluphenazine on the genotoxicity of standard mutagens was strongest in the cytokinesis-blocked micronucleus assay and in the thioguanine-resistance test, and weakest in the sister chromatid exchange test. Fluphenazine also considerably reduced the level of free radicals estimated in irt vitro samples of human granulocytes. The results suggest that, in the range of the tested concentrations, fluphenazine could be considered for useto prevent the genotoxicity of daunorubicin, methyl methanesulfonate, benzo[a]pyrene and mitomycin C. Reduction in the level of free radicals appearsto be an important mechanism of the antimutagenic action of fluphenazine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:01:55