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Titolo:
Distribution of dopamine D1 receptors in the nucleus paraventricularis of the hypothalamus in rats: an immunohistochemical study
Autore:
Czyrak, A; Chocyk, A; Mackowiak, M; Fijal, K; Wedzony, K;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 85, anno: 2000,
pagine: 209 - 217
SICI:
0169-328X(200012)85:1-2<209:DODDRI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARVOCELLULAR NEUROSECRETORY NEURONS; MEDIAL ZONA INCERTA; TRANSCRIPTIONAL ACTIVATION; INDUCED SENSITIZATION; RESPONSIVE ELEMENT; HORMONE NEURONS; FOS-EXPRESSION; MESSENGER-RNA; STRESS; BRAIN;
Keywords:
nucleus paraventricularis of the hypothalamus; dopamine D1 receptor; immunohistochemistry; western blot; double labeling; pCREB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Wedzony, K Polish Acad Sci, Inst Pharmacol, 12 Smetna St, PL-31343 Krakow,Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 ow, Poland
Citazione:
A. Czyrak et al., "Distribution of dopamine D1 receptors in the nucleus paraventricularis of the hypothalamus in rats: an immunohistochemical study", MOL BRAIN R, 85(1-2), 2000, pp. 209-217

Abstract

The present study investigated the distribution of dopamine D1 receptor protein in the nucleus paraventricularis of the hypothalamus. It was found that the nucleus paraventricularis of the hypothalamus contains a relatively large number of cells which are positive for presence of dopamine D1 receptor protein. The vast majority of dopamine D1 receptor-positive neurons was found in the magnocellular part, but they were also present in considerablequantity in the parvocellular part of this subregion of the hypothalamus. When measured by the Western blot technique, the quantity of D1 receptor protein found in the paraventricular nucleus of the hypothalamus was at the level found in the prefrontal cortex. It was also found that dopamine D1 receptor protein was present in neurons constitutively displaying phosphorylated CREB protein, i.e, neurons which are, as might be speculated, under the tonic influence of neurotransmitters whose receptors operate via cAMP and pCREB as second or third messengers. The presence of dopamine D1 receptors in the nucleus paraventricularis of the hypothalamus may suggest, at an anatomical level, that these receptors are involved in controlling the release of hormones, as well as their synthesis at the level of transcription, which is regulated by phosphorylation of CREB protein. Finally, the present immunocytochemical findings offer an anatomical substrate for the role of dopamine and its receptors of D1 subtype in the regulation of the activity of paraventricular neurons seen in the functional studies. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:22:59