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Titolo:
Nucleotide sequence variation at two genes of the phenylpropanoid pathway,the FAH1 and F3H genes, in Arabidopsis thaliana
Autore:
Aguade, M;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 1, volume: 18, anno: 2001,
pagine: 1 - 9
SICI:
0737-4038(200101)18:1<1:NSVATG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR POPULATION-GENETICS; UV-B RADIATION; CHALCONE SYNTHASE; DNA VARIATION; ADH LOCUS; POLYMORPHISM; EVOLUTION; MUTANTS; REGION; RECOMBINATION;
Keywords:
polymorphism; divergence; Arabidopsis thaliana; Arabidopsis lyrata;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Aguade, M Univ Barcelona, Fac Biol, Dept Genet, Diagonal 645, E-08071 Barcelona, Spain Univ Barcelona Diagonal 645 Barcelona Spain E-08071 lona, Spain
Citazione:
M. Aguade, "Nucleotide sequence variation at two genes of the phenylpropanoid pathway,the FAH1 and F3H genes, in Arabidopsis thaliana", MOL BIOL EV, 18(1), 2001, pp. 1-9

Abstract

The FAH1 and F3H genes encode ferulate-5-hydroxylase and flavanone-3-hydroxylase, which are enzymes in the pathways leading to the synthesis of sinapic acid esters and flavonoids, respectively. Nucleotide variation at these genes was surveyed by sequencing a sample of 20 worldwide Arabidopsis thaliana ecotypes and one Arabidopsis lyrata spp, petraea stock. In contrast with most previously studied genes, the percentage of singletons was rather low in both the FAH1 and the F3H gene regions. There was, therefore, no footprint of a recent species expansion in the pattern of nucleotide variation in these regions. In both FAH1 and F3H, nucleotide variation was structured into two major highly differentiated haplotypes. In both genes, there was apeak of silent polymorphism in the 5' part of the coding region without a parallel increase in silent divergence. In FAH1, the peak was centered at the beginning of the second exon. In F3H, nucleotide diversity was highest at the beginning of the gene. The observed pattern of variation in both FAH1and F3H, although suggestive of balancing selection, was compatible with aneutral model with no recombination.

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Documento generato il 04/12/20 alle ore 13:28:48